Special Issue "Mycobacterial Effectors Promoting Tuberculosis Infection"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editors

Guest Editor
Dr. Romain Veyron-Churlet

Université de Lille, CNRS UMR8204, INSERM U1019, CHU Lille, Centre d’Infection et d’Immunité de Lille, Institut Pasteur de Lille, 59000 Lille, France
Website | E-Mail
Interests: tuberculosis; host-pathogen interactions; Mycobacterium; cell wall; protein-protein interactions
Guest Editor
Dr. Arnaud Machelart

Université de Lille, CNRS UMR8204, INSERM U1019, CHU Lille, Centre d’Infection et d’Immunité de Lille, Institut Pasteur de Lille, 59000 Lille, France
E-Mail
Interests: tuberculosis; host-pathogen interactions; Mycobacterium; cell signaling; immune response; host directed therapies; macrophages; lung diseases

Special Issue Information

Dear Colleagues,

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which is the first leading cause of death around the world due to a single infectious agent. In 2017, TB killed an estimated 1.6 million people, according to the WHO. In addition, there is an alarming increase of multi-resistant drug TB cases. Therefore, understanding the mechanisms leading to the development of the disease is urgently needed to develop efficient strategies against TB.

Mtb is a successful pathogen, which, upon inhalation, is able to infect the host alveolar macrophages. The bacilli is able to prevent the acidification of its containing vacuole by blocking the phagosomal maturation. During its vacuolar lifetime, Mtb is able to survive in this harsh environment by resisting the host immune response and scavenging the nutrients necessary for its survival (like lipids or iron). Ultimately, Mtb can escape the vacuole and reside inside the cell cytoplasm.

Therefore, Mtb has developed a huge set of mechanisms to promote its survival and massively replicate during its prolonged stay in the host. Several virulence factors of Mtb have been identified with the help of genetic tools and animal models. Among the most studied mycobacterial effectors, one can cite the ESX/type VII secretion system substrates (ESAT-6/CFP-10), the eukaryotic-like protein kinase (PknG), as well as several components of the very peculiar mycobacterial cell wall (PDIM, mycolic acids). Nonetheless, many other mechanisms remain to be identified and characterized to gain a better understanding of TB pathogenesis.

For this Special Issue of Pathogens, we kindly invite authors to submit an original research article or a review focusing on the mycobacterial effectors promoting TB infection. Potential topics could include (but are not limited to): host–pathogen interactions, virulence factors of Mtb, intravacuolar and/or intracytoplasmic survival of Mtb, mechanisms of resistance, and interference with host cell signaling.

Dr. Romain Veyron-Churlet
Dr. Arnaud Machelart
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tuberculosis
  • infection
  • Mycobacterium
  • host–pathogen interactions
  • virulence factors
  • mechanisms of resistance

Published Papers

This special issue is now open for submission.
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