Special Issue "Mycobacterial Effectors Promoting Tuberculosis Infection"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 June 2020).
Interests: tuberculosis; host-pathogen interactions; Mycobacterium; cell wall; protein-protein interactions
Interests: tuberculosis; host-pathogen interactions; Mycobacterium; cell signaling; immune response; host directed therapies; macrophages; lung diseases
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which is the first leading cause of death around the world due to a single infectious agent. In 2017, TB killed an estimated 1.6 million people, according to the WHO. In addition, there is an alarming increase of multi-resistant drug TB cases. Therefore, understanding the mechanisms leading to the development of the disease is urgently needed to develop efficient strategies against TB.
Mtb is a successful pathogen, which, upon inhalation, is able to infect the host alveolar macrophages. The bacilli is able to prevent the acidification of its containing vacuole by blocking the phagosomal maturation. During its vacuolar lifetime, Mtb is able to survive in this harsh environment by resisting the host immune response and scavenging the nutrients necessary for its survival (like lipids or iron). Ultimately, Mtb can escape the vacuole and reside inside the cell cytoplasm.
Therefore, Mtb has developed a huge set of mechanisms to promote its survival and massively replicate during its prolonged stay in the host. Several virulence factors of Mtb have been identified with the help of genetic tools and animal models. Among the most studied mycobacterial effectors, one can cite the ESX/type VII secretion system substrates (ESAT-6/CFP-10), the eukaryotic-like protein kinase (PknG), as well as several components of the very peculiar mycobacterial cell wall (PDIM, mycolic acids). Nonetheless, many other mechanisms remain to be identified and characterized to gain a better understanding of TB pathogenesis.
For this Special Issue of Pathogens, we kindly invite authors to submit an original research article or a review focusing on the mycobacterial effectors promoting TB infection. Potential topics could include (but are not limited to): host–pathogen interactions, virulence factors of Mtb, intravacuolar and/or intracytoplasmic survival of Mtb, mechanisms of resistance, and interference with host cell signaling.
Dr. Romain Veyron-Churlet
Dr. Arnaud Machelart
Manuscript Submission Information
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- host–pathogen interactions
- virulence factors
- mechanisms of resistance