Special Issue "Mycobacterial Effectors Promoting Tuberculosis Infection"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editors

Dr. Romain Veyron-Churlet
Website
Guest Editor
Université de Lille, CNRS UMR8204, INSERM U1019, CHU Lille, Centre d’Infection et d’Immunité de Lille, Institut Pasteur de Lille, 59000 Lille, France
Interests: tuberculosis; host-pathogen interactions; Mycobacterium; cell wall; protein-protein interactions
Dr. Arnaud Machelart

Guest Editor
Université de Lille, CNRS UMR8204, INSERM U1019, CHU Lille, Centre d’Infection et d’Immunité de Lille, Institut Pasteur de Lille, 59000 Lille, France
Interests: tuberculosis; host-pathogen interactions; Mycobacterium; cell signaling; immune response; host directed therapies; macrophages; lung diseases

Special Issue Information

Dear Colleagues,

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which is the first leading cause of death around the world due to a single infectious agent. In 2017, TB killed an estimated 1.6 million people, according to the WHO. In addition, there is an alarming increase of multi-resistant drug TB cases. Therefore, understanding the mechanisms leading to the development of the disease is urgently needed to develop efficient strategies against TB.

Mtb is a successful pathogen, which, upon inhalation, is able to infect the host alveolar macrophages. The bacilli is able to prevent the acidification of its containing vacuole by blocking the phagosomal maturation. During its vacuolar lifetime, Mtb is able to survive in this harsh environment by resisting the host immune response and scavenging the nutrients necessary for its survival (like lipids or iron). Ultimately, Mtb can escape the vacuole and reside inside the cell cytoplasm.

Therefore, Mtb has developed a huge set of mechanisms to promote its survival and massively replicate during its prolonged stay in the host. Several virulence factors of Mtb have been identified with the help of genetic tools and animal models. Among the most studied mycobacterial effectors, one can cite the ESX/type VII secretion system substrates (ESAT-6/CFP-10), the eukaryotic-like protein kinase (PknG), as well as several components of the very peculiar mycobacterial cell wall (PDIM, mycolic acids). Nonetheless, many other mechanisms remain to be identified and characterized to gain a better understanding of TB pathogenesis.

For this Special Issue of Pathogens, we kindly invite authors to submit an original research article or a review focusing on the mycobacterial effectors promoting TB infection. Potential topics could include (but are not limited to): host–pathogen interactions, virulence factors of Mtb, intravacuolar and/or intracytoplasmic survival of Mtb, mechanisms of resistance, and interference with host cell signaling.

Dr. Romain Veyron-Churlet
Dr. Arnaud Machelart
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tuberculosis
  • infection
  • Mycobacterium
  • host–pathogen interactions
  • virulence factors
  • mechanisms of resistance

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Open AccessReview
In Vivo Methods to Study Protein–Protein Interactions as Key Players in Mycobacterium Tuberculosis Virulence
Pathogens 2019, 8(4), 173; https://doi.org/10.3390/pathogens8040173 - 01 Oct 2019
Cited by 1
Abstract
Studies on protein–protein interactions (PPI) can be helpful for the annotation of unknown protein functions and for the understanding of cellular processes, such as specific virulence mechanisms developed by bacterial pathogens. In that context, several methods have been extensively used in recent years [...] Read more.
Studies on protein–protein interactions (PPI) can be helpful for the annotation of unknown protein functions and for the understanding of cellular processes, such as specific virulence mechanisms developed by bacterial pathogens. In that context, several methods have been extensively used in recent years for the characterization of Mycobacterium tuberculosis PPI to further decipher tuberculosis (TB) pathogenesis. This review aims at compiling the most striking results based on in vivo methods (yeast and bacterial two-hybrid systems, protein complementation assays) for the specific study of PPI in mycobacteria. Moreover, newly developed methods, such as in-cell native mass resonance and proximity-dependent biotinylation identification, will have a deep impact on future mycobacterial research, as they are able to perform dynamic (transient interactions) and integrative (multiprotein complexes) analyses. Full article
(This article belongs to the Special Issue Mycobacterial Effectors Promoting Tuberculosis Infection)
Show Figures

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

The authors showed their interests in contributing to the Special Issue:

Carlos Martin, Universidad de Zaragoza, Facultad de Medicina, Zaragoza, Spain

Yann Guérardel, French National Centre for Scientific Research, CNRS · UGSF, UMR 8576

Back to TopTop