SARS-CoV-2 Spike-Based Vaccines
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "COVID-19 Vaccines and Vaccination".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3687
Special Issue Editors
Interests: SARS-CoV-2; viruses; proteomics; structural biology; neoantigen vaccine; antigen presentation; mRNA degradation
Interests: MHC-I; cancer mutations; molecular dynamics; viruses; spike; SARS-CoV-2; antigen processing; transporters; membranes
2. Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK
Interests: human herpesviruses; neurodegenerative diseases; COVID-19
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The SARS-CoV (β-CoV) outbreaks in 2003 and 2019 created an epidemic and a pandemic, and SARS-CoV-2 has mutated into several variants thus far. Structurally, SARS-CoV-2 is a nanostructural system consisting of nuclear material surrounded by coat proteins, including a spike (S) glycoprotein. The S protein is most crucial in ACE2 host-cell receptor binding, and hence, it is a main target of the immune system. Though the mortality caused by these β-CoV is substantial, a promising strategy and long-term solution to treat patients infected with the virus is still required. One effective method is to design innovative strategies to develop preventative vaccines considering proteins from the SARS-CoV-2 coronavirus itself. These self-derived vaccines can have several significant impacts on understanding β-CoV; they can induce immune responses, a critical component for vaccinology, and can trigger the production of an antibody repertoire. Despite the significant threat that COVID-19 variants pose to current vaccines, these mutations in the S protein can guide novel current/future key vaccines strategies. This Special Issue aims to gather research (reviews, short reports, hypotheses, research articles, etc.) that addresses all aspects of spike-based vaccine development and the implications of variants.
Dr. Umesh Kalathiya
Dr. Monikaben Padariya
Dr. Peter Maple
Guest Editors
Manuscript Submission Information
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Keywords
- SARS-CoV-2
- spike
- ACE2
- structural biology
- vaccine
- receptor-binding domains
- self-derived vaccines
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