Special Issue "SARS-CoV-2 Spike-Based Vaccines"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "COVID-19 Vaccines and Vaccination".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 412

Special Issue Editors

International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdańsk, Poland
Interests: SARS-CoV-2; viruses; proteomics; structural biology; neoantigen vaccine; antigen presentation; mRNA degradation
International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdańsk, Poland
Interests: MHC-I; cancer mutations; molecular dynamics; viruses; spike; SARS-CoV-2; antigen processing; transporters; membranes
Research Group in Clinical Neurology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
Interests: interactions of herpesviruses infections with autoimmune/inflammatory mediated neurological diseases
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Special Issue Information

Dear Colleagues, 

The SARS-CoV (β-CoV) outbreaks in 2003 and 2019 created an epidemic and a pandemic, and SARS-CoV-2 has mutated into several variants thus far. Structurally, SARS-CoV-2 is a nanostructural system consisting of nuclear material surrounded by coat proteins, including a spike (S) glycoprotein. The S protein is most crucial in ACE2 host-cell receptor binding, and hence, it is a main target of the immune system. Though the mortality caused by these β-CoV is substantial, a promising strategy and long-term solution to treat patients infected with the virus is still required. One effective method is to design innovative strategies to develop preventative vaccines considering proteins from the SARS-CoV-2 coronavirus itself. These self-derived vaccines can have several significant impacts on understanding β-CoV; they can induce immune responses, a critical component for vaccinology, and can trigger the production of an antibody repertoire. Despite the significant threat that COVID-19 variants pose to current vaccines, these mutations in the S protein can guide novel current/future key vaccines strategies. This Special Issue aims to gather research (reviews, short reports, hypotheses, research articles, etc.) that addresses all aspects of spike-based vaccine development and the implications of variants.

Dr. Umesh Kalathiya
Dr. Monikaben Padariya
Dr. Peter Maple
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • SARS-CoV-2
  • spike
  • ACE2
  • structural biology
  • vaccine
  • receptor-binding domains
  • self-derived vaccines

Published Papers

There is no accepted submissions to this special issue at this moment.
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