Animal Virus Infection, Immunity and Vaccines: 2nd Edition

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 1365

Special Issue Editor


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Guest Editor
Department of Pathology, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium
Interests: zoonotic and veterinary diseases; viruses; vaccinology; immunology
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on zoonotic and livestock viral diseases, particularly emphasizing infection and immunity. Topics of interest may include studies on novel infection models or systems, the development of vaccine candidates, and the validation of new diagnostic tools for detecting viral agents. We are especially interested in studies that examine the immunological consequences of natural infections or vaccinations. These may encompass measuring antibody titers, classifying T-cell populations, or characterizing innate immune responses.

Dr. Hani Boshra
Guest Editor

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Keywords

  • zoonotic and veterinary diseases
  • viruses
  • vaccinology
  • immunology

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Published Papers (1 paper)

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9 pages, 597 KB  
Brief Report
Field Evidence of Fasciola hepatica-Mediated Modulation of Antibody Responses to Foot-and-Mouth Disease Vaccination in Buffaloes
by Juan Manuel Sala, Maximiliano Wilda, María Cruz Miraglia, Mariángeles Castillo, Daniel Mariano Pérez-Filgueira, Teresa Freire and Alejandra Victoria Capozzo
Vaccines 2026, 14(1), 36; https://doi.org/10.3390/vaccines14010036 - 28 Dec 2025
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Abstract
Background: Fasciola hepatica (F. hepatica) infection reduces antibody avidity to foot-and-mouth disease virus (FMDV) vaccination in cattle despite preserved total antibody levels. However, its effect on vaccine-induced immunity in water buffaloes (Bubalus bubalis), which contribute to FMDV maintenance in endemic settings, [...] Read more.
Background: Fasciola hepatica (F. hepatica) infection reduces antibody avidity to foot-and-mouth disease virus (FMDV) vaccination in cattle despite preserved total antibody levels. However, its effect on vaccine-induced immunity in water buffaloes (Bubalus bubalis), which contribute to FMDV maintenance in endemic settings, has not been investigated. Objectives: To evaluate the effect of natural F. hepatica infection on the magnitude and functional quality of the FMDV–specific antibody response in buffaloes under field conditions. Methods: Two buffalo herds (n = 50 each) were classified by infection status using coproparasitological analysis and serology. All animals were vaccinated within the national foot-and-mouth disease control programme, with the last dose administered 264 days before sampling. Serum neutralising titres, total antibodies by liquid-phase blocking ELISA, IgG levels, and IgG avidity to the A24/Cruzeiro vaccine strain were determined. Results: F. hepatica-infected buffaloes exhibited consistent decreases across all vaccine-induced antibody parameters. Neutralising titres were reduced approximately two-fold, IgG avidity by about 38 percent, IgG levels by about 36 percent, and liquid-phase blocking ELISA titres by about 1.6-fold compared with non-infected animals. Conclusions: This study provides the first field evidence that fasciolosis is associated with changes in the magnitude and quality of vaccine-induced humoral responses following FMDV vaccination in water buffaloes, indicating that F. hepatica infection may influence the interpretation of post-vaccination serological monitoring in this species under endemic field conditions. Full article
(This article belongs to the Special Issue Animal Virus Infection, Immunity and Vaccines: 2nd Edition)
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