Advances in Immunotherapy of Cancer

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccination Against Cancer and Chronic Diseases".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 2238

Special Issue Editors


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Guest Editor
School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China
Interests: immunology and microbiology; modern biotechnology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, China
Interests: cancer metabolism and immunotherapy

Special Issue Information

Dear Colleagues,

Cancer vaccines have emerged as a transformative approach in oncology, leveraging the immune system to target and eliminate malignant cells. Based on the deep understanding of tumor immunity and great improvements in biotechnology and artificial intellengence (AI), cancer vaccines have become increasingly prominent in cancer immunotherapies.

We are pleased to invite you to contribute to this Special Issue, Advances in Immunotherapy of Cancer, of the Vaccines journal, aimed at reporting new advances in cancer vaccines and cancer immunotherapy, such as new cancer vaccines, new technology for cancer vaccine development, and the immunomechanism of cancer vaccines.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • immunomechanism of cancer vaccines;
  • mRNA-based cancer vaccines;
  • tumor neoantigens;
  • peptide-based vaccines;
  • adjuvant;
  • antigen finding and AI-driven antigen prediction;
  • combination therapies;
  • vaccine delivery.

We look forward to receiving your contributions.

Prof. Dr. Li Ye
Dr. Jiajun Fan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer vaccines
  • neoantigen
  • immunotherapy
  • cancer microenviroment

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Published Papers (1 paper)

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Research

22 pages, 7902 KB  
Article
CD63-Mediated SARS-CoV-2 RBD Fusion Neoantigen DNA Vaccine Enhances Antitumor Immune Response in a Mouse Panc02 Model via EV-Targeted Delivery
by Guang Liu, Ziqing Yuan, Ziyi Wu, Qiyv Yang, Tingbo Ding, Ker Yu and Jibin Dong
Vaccines 2025, 13(9), 977; https://doi.org/10.3390/vaccines13090977 - 16 Sep 2025
Cited by 1 | Viewed by 1709
Abstract
Background: Although DNA vaccines offer a flexible platform for tumor immunotherapy, their weak immunogenicity remains a key limitation. This study aimed to improve the immunogenicity of DNA vaccines by enhancing the efficiency of tumor neoantigen delivery through extracellular vesicles (EVs), thereby promoting stronger [...] Read more.
Background: Although DNA vaccines offer a flexible platform for tumor immunotherapy, their weak immunogenicity remains a key limitation. This study aimed to improve the immunogenicity of DNA vaccines by enhancing the efficiency of tumor neoantigen delivery through extracellular vesicles (EVs), thereby promoting stronger dendritic cell (DC) activation and antitumor responses. Methods: A novel DNA vaccine (pCSP) was engineered by fusing tumor-specific neoantigens to the EV-associated protein CD63 and incorporating a SARS-CoV-2 receptor-binding domain (RBD) fragment to facilitate EV uptake by DCs. The resulting EVs were expected to carry neoantigens into the immunoproteasome for major histocompatibility complex I (MHC-I) presentation. The immunological and antitumor effects of pCSP were assessed through in vitro functional assays and in vivo experiments in a murine pancreatic cancer model. Safety was evaluated through histological and biochemical analyses. Results: In vitro, pCSP significantly promoted EV internalization by DCs by approximately twofold and enhanced their immune activation, as evidenced by elevated cytokine production. In vivo, pCSP markedly suppressed tumor growth with a decrease in volume by over 70% relative to controls, boosted CD8+ T cell responses, and increased immune infiltration into the tumor microenvironment. Safety assessments revealed that while liver/kidney function markers were within physiological ranges, mild inflammatory infiltrates were consistently observed in the lungs, indicating a localized safety concern that warrants further monitoring. Conclusions: The pCSP vaccine enhances the immunogenicity of neoantigen DNA vaccines by improving EV uptake and immune activation in DCs. These findings provide a potential strategy for improving DNA vaccine efficacy in the context of cancer immunotherapy while maintaining acceptable safety. Full article
(This article belongs to the Special Issue Advances in Immunotherapy of Cancer)
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