New Perspectives in Tuberculosis Prevention and Control

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: 5 December 2025 | Viewed by 2023

Special Issue Editor


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Guest Editor
Senior Operational Research Fellow, Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France
Interests: TB preventive therapy; TB treatment adherence; TB-associated disability; quality of non-communicable disease; primary care; operational research
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Dear Colleagues,

Globally, tuberculosis remains a major public health concern, despite the progress made in reducing morbidity and mortality in the last two decades. The World Health Organization estimated that about 10.6 million patients had incident TB in 2022, a reduction of about 9% from what had been estimated in 2015. Although global and national TB programs are making the utmost efforts to meet the end TB target of reducing TB incidence by 80% by 2030 compared to 2015, with the current rate of reduction, this target looks far-fetched.

While there are several interventions proven to reduce the incidence of TB, their implementation remains suboptimal. There is a need to effectively implement interventions such as early diagnosis and treatment of patients for TB, infection prevention and control at health facilities, communities, and congregate settings, tuberculosis preventive therapy for high-risk groups, implementation of the multisectoral accountability framework, adult vaccination, and concentrated efforts on TB prevention in key and vulnerable groups. Any new perspectives on optimizing and effectively implementing the above interventions would help national TB programs to scale up these interventions in their countries. Thus, these new perspectives on TB prevention and control would help the global community meet the ambitious end of TB targets by 2035.

In this regard, we request that you submit your research work related to any of the interventions mentioned above to this Special Issue on “New perspectives in tuberculosis prevention and Control”. To ensure research uptake and cross-learning, this Special Issue will be widely circulated among researchers, academicians, and policymakers involved in TB control.

Dr. Pruthu Thekkur
Guest Editor

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Keywords

  • tuberculosis infection
  • early diagnosis
  • tuberculosis treatment adherence
  • tuberculosis preventive therapy
  • adult vaccination for tuberculosis
  • multisectoral accountability framework
  • tuberculosis infection prevention and control
  • end TB strategy
  • key and vulnerable populations for TB
  • operational research

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Published Papers (2 papers)

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Research

15 pages, 1251 KB  
Article
Understanding Patient Experiences: A Mixed-Methods Study on Barriers and Facilitators to TB Care-Seeking in South Africa
by Farzana Sathar, Claire du Toit, Violet Chihota, Salome Charalambous, Denise Evans and Candice Chetty-Makkan
Trop. Med. Infect. Dis. 2025, 10(10), 283; https://doi.org/10.3390/tropicalmed10100283 - 3 Oct 2025
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Abstract
Introduction: Tuberculosis (TB) remains a public health concern, and people at risk for TB are hesitant to seek care. The first South African National TB prevalence survey, conducted in 2017–2019, found that most participants with TB symptoms did not seek care for TB. [...] Read more.
Introduction: Tuberculosis (TB) remains a public health concern, and people at risk for TB are hesitant to seek care. The first South African National TB prevalence survey, conducted in 2017–2019, found that most participants with TB symptoms did not seek care for TB. In 2022, an estimated 23% of people with TB in South Africa were undiagnosed, contributing to the country’s burden of “missing” TB cases. This study explores health-seeking behaviour among people with TB (PwTB) in South Africa, focussing on barriers and facilitators to care-seeking and the quantification of TB-related stigma from a patient and community perspective. Methods: We conducted a mixed-method study in the City of Johannesburg (COJ) Metropolitan Municipality from February to March 2022. PwTB aged 18 and older initiating TB treatment for microbiologically confirmed pulmonary TB were recruited from three primary healthcare facilities in the COJ. After providing written informed consent, they participated in a one-time, in-depth, face-to-face interview. The interviews were digitally recorded and conducted by trained facilitators. We used thematic analysis with deductive approaches to develop themes. We used the Van Rie TB stigma assessment scale to quantify perceived stigma. Results: We interviewed 23 PwTB with an overall median age of 39 years and 14 (61%) males. Patient-level barriers to accessing TB care included visiting traditional healers and pharmacists before their TB diagnosis; wrong or missed diagnosis by private doctors; work commitments; scarcity of resources to attend the clinic or walk long distances; perceived and experienced stigma; and a lack of TB knowledge. Facility-level barriers included long clinic queues and uncertainty about where to receive TB care in the clinic. Facilitators for TB care-seeking included being in contact with someone who had TB, receiving encouragement from family, or having knowledge about TB transmission and early diagnosis. The overall median total stigma score among 21 PwTB was 53 (IQR: 46–63), with median community and patient stigma scores of 25 (IQR: 22–30) and 31 (IQR: 21–36), respectively. Conclusions: We found important considerations for the TB programme to improve the uptake of services. Since PwTB consult elsewhere before visiting a facility for TB care, TB programmes could establish private–public partnerships. TB programmes could also increase TB awareness in the community, especially among males, and mobile clinics could be considered to assist with TB case detection and treatment provision. Applying behavioural design techniques and co-designing interventions with patients and providers could improve TB health-seeking behaviours. Full article
(This article belongs to the Special Issue New Perspectives in Tuberculosis Prevention and Control)
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11 pages, 422 KB  
Article
Prevalence, Conversion and Reversion of Tuberculosis Infection Among Healthcare Workers of Tertiary Care Centres in Puducherry, India: A Prospective Cohort Study
by Sadhana Subramanian, Palanivel Chinnakali, Senbagavalli Prakashbabu, Guha Nandhini Visvanadane, Manju Rajaram, Vijay Viswanathan, Sonali Sarkar and Charles Robert Horsburgh
Trop. Med. Infect. Dis. 2025, 10(5), 141; https://doi.org/10.3390/tropicalmed10050141 - 20 May 2025
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Abstract
Healthcare workers (HCWs) face an increased risk of tuberculosis (TB) due to occupational exposure. This study aimed to estimate the point prevalence of TB infection (TBI) from the initial test performed, while the reversion and conversion were done by subsequent testing at one [...] Read more.
Healthcare workers (HCWs) face an increased risk of tuberculosis (TB) due to occupational exposure. This study aimed to estimate the point prevalence of TB infection (TBI) from the initial test performed, while the reversion and conversion were done by subsequent testing at one year among HCWs in Puducherry, India. A prospective cohort study was conducted among a sample of proportionately chosen HCWs based on their occupational strata of a tertiary hospital in 2022. TBI was assessed using IGRA (4th generation QuantiFeron—TB gold plus kits) after TB symptom screening. The IGRA test was repeated at the end of one year. Reversion was defined as a positive IGRA test at the baseline and had values < 0.2 IU/L in TB1 or TB2 tubes during follow-up. Conversion was defined as a negative IGRA result at the baseline and had values of >0.7 IU/L in TB1 or TB2 tubes during follow-up. Of the 400 HCWs included, the mean (SD) age was 37 (7) years. Median (IQR) work experience was 15.7 (10–21) years. TBI was seen in 150 HCWs (37.7%, 95% CI: 33.0–42.7), and one had active TB. A total of 128/150 HCWs with TBI at baseline were followed up, and 15 had TBI reversion (11.7 per 100 person-years; 95% CI: 6.7–18.5). Thirteen HCWs (5.6 per 100 person-years; 95% CI: 3.3–9.8) had TBI conversion. Full article
(This article belongs to the Special Issue New Perspectives in Tuberculosis Prevention and Control)
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