Mycotoxin Biomarkers of Exposure

Dear Colleagues,

Dietary exposure to mycotoxins remains a daily fact for humans worldwide. In the last decade, a focus has been placed on assessments of external dietary exposure identifying globally high incidences of mycotoxins in our diets. However, currently, the use of mycotoxin biomarkers to determine internal dietary exposure is becoming more commonplace.

Biomarker-driven research has been proposed as a successful method to assess individuals’ exposure to mycotoxins through an estimation of their metabolites in biological fluids (i.e. biomarkers of exposure). Next to the analytical challenges of determining and identifying mycotoxin biomarkers of exposure, it is a challenge to identify, validate and prove the relevance of these biomarkers. There is also need to characterize a biomarker’s effectiveness or utility as a surrogate endpoint, as well as its ability to provide clinically relevant information on research questions. Well-characterized biomarkers that have been shown to predict clinical outcomes across a variety of populations, however, remain a rarity in the mycotoxin research field.

This Special Issue of Toxins ‘Mycotoxin Biomarkers’ aims to provide a comprehensive holistic look at mycotoxin biomarkers of exposure highlighting analytical methodologies to determine mycotoxin biomarkers (both rapid screening and LC-MS/HRMS-based approaches), survey analyses of mycotoxin biomarkers, in vitro analyses that unravel possible new mycotoxin biomarkers, in vivo analyses validating biomarkers of exposure, toxicokinetic studies with a focus on the biomarkers of exposure profiles, and assessment studies linking mycotoxin biomarkers to clinical outcomes.

Dr. Marthe De Boevre
Guest Editor

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