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Toxins 2018, 10(10), 387; https://doi.org/10.3390/toxins10100387

Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins

Université Grenoble Alpes, CNRS ERL5261, CEA BIG-BCI, INSERM UMR1036, Grenoble 38054, France
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Received: 3 September 2018 / Revised: 14 September 2018 / Accepted: 20 September 2018 / Published: 25 September 2018
(This article belongs to the Special Issue Bacterial Pore-Forming Toxins)
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Abstract

Bacterial pore-forming toxins induce a rapid and massive increase in cytosolic Ca2+ concentration due to the formation of pores in the plasma membrane and/or activation of Ca2+-channels. As Ca2+ is an essential messenger in cellular signaling, a sustained increase in Ca2+ concentration has dramatic consequences on cellular behavior, eventually leading to cell death. However, host cells have adapted mechanisms to protect against Ca2+ intoxication, such as Ca2+ efflux and membrane repair. The final outcome depends upon the nature and concentration of the toxin and on the cell type. This review highlights the repercussions of Ca2+ overload on the induction of cell death, repair mechanisms, cellular adhesive properties, and the inflammatory response. View Full-Text
Keywords: host–pathogen interaction; bacterial virulence factor; cell death; signal transduction; ion flux host–pathogen interaction; bacterial virulence factor; cell death; signal transduction; ion flux
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Bouillot, S.; Reboud, E.; Huber, P. Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins. Toxins 2018, 10, 387.

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