Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
AbstractPermeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break plasma membrane integrity and cause cell death by colloid-osmotic lysis. Eukaryotic cells, in turn, have developed different ways to cope with the effects of such membrane piercing. Here, we provide a short overview of the general mechanisms currently proposed for plasma membrane repair, focusing more specifically on the cellular responses to membrane permeabilization by pore-forming toxins and presenting new data on the effects and cellular responses to the permeabilization by an RTX (repeats in toxin) toxin, the adenylate cyclase toxin-hemolysin secreted by the whooping cough bacterium Bordetella pertussis, which we have studied in the laboratory. View Full-Text
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Etxaniz, A.; González-Bullón, D.; Martín, C.; Ostolaza, H. Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins. Toxins 2018, 10, 234.
Etxaniz A, González-Bullón D, Martín C, Ostolaza H. Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins. Toxins. 2018; 10(6):234.Chicago/Turabian Style
Etxaniz, Asier; González-Bullón, David; Martín, César; Ostolaza, Helena. 2018. "Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins." Toxins 10, no. 6: 234.
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