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Toxins 2018, 10(6), 234;

Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins

Biofisika Institute (UPV/EHU, CSIC) and University of the Basque Country (UPV/EHU) Parque Científico s/n, 48940 Leioa, Spain
Author to whom correspondence should be addressed.
Received: 24 May 2018 / Revised: 4 June 2018 / Accepted: 7 June 2018 / Published: 9 June 2018
(This article belongs to the Special Issue Bacterial Pore-Forming Toxins)
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Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis. Numerous pathogenic bacteria produce pore-forming toxins that break plasma membrane integrity and cause cell death by colloid-osmotic lysis. Eukaryotic cells, in turn, have developed different ways to cope with the effects of such membrane piercing. Here, we provide a short overview of the general mechanisms currently proposed for plasma membrane repair, focusing more specifically on the cellular responses to membrane permeabilization by pore-forming toxins and presenting new data on the effects and cellular responses to the permeabilization by an RTX (repeats in toxin) toxin, the adenylate cyclase toxin-hemolysin secreted by the whooping cough bacterium Bordetella pertussis, which we have studied in the laboratory. View Full-Text
Keywords: membrane permeabilization; membrane repair; pore-forming toxins; RTX toxins; adenylate cyclase toxin; Bordetella pertussis membrane permeabilization; membrane repair; pore-forming toxins; RTX toxins; adenylate cyclase toxin; Bordetella pertussis

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Etxaniz, A.; González-Bullón, D.; Martín, C.; Ostolaza, H. Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins. Toxins 2018, 10, 234.

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