Special Issue "Mycotoxins and Their Metabolites Biochemistry, Molecular Biology and Toxicology"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editor

Prof. Dr. Kamil Kuca
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Guest Editor
Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
Interests: Antidotes for pesticide and nerve agent poisonings; Alzheimer’s disease treatment; Detergents as disinfectants, nanoparticles; decontamination means; Toxins; Drug design and development; Nanotechnology; IT, parallel computing, ANN; Project management; Scientific management; Technology Transfer; Health economics and Pharmacoeconomics
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Special Issue Information

Mycotoxins comprise hundreds of toxic secondary metabolites that are produced by fungi and contaminate cereal grains, leading to serious effects on human and animal health. Pathophysiologic effects associated with mycotoxins include immunosuppression, altered neuroendocrine signaling, proinflammatory gene induction, malnutrition, disruption of the growth hormone axis, carcinogenesis, and reproductive and teratogenic effects. Exposure routes, bioavailability, and potential accumulation of mycotoxins in different species or organs can lead to different toxicities. Although the toxicity of most metabolites has been reduced compared with the original mycotoxins, they are still extremely harmful to humans and animals, suggesting that further investigations into toxicity are necessary. As more and more novel mycotoxins and metabolites are discovered, there is increasing interest in studying the toxicity and molecular mechanisms of these toxins and their major metabolites. This Special Issue of Toxins is focused on new insights and advances in cellular and molecular mechanisms of toxicity induced by mycotoxins and their major metabolites, especially from biochemistry and signaling pathways that underlie these toxic responses. While the focus is on molecular biology and toxicology of mycotoxins and metablites, manuscripts addressing the occurrence, contamination, and risk assessment of novel mycotoxins and metabolites will also be considered.

Prof. Dr. Kamil Kuca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycotoxins
  • metabolites
  • toxicology
  • molecular mechanisms

Published Papers (1 paper)

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Research

Open AccessArticle
Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink
Toxins 2020, 12(6), 419; https://doi.org/10.3390/toxins12060419 - 25 Jun 2020
Abstract
The trichothecene mycotoxins contaminate cereal grains and have been related to alimentary toxicosis resulted in emetic response. This family of mycotoxins comprises type A to D groups of toxic sesquiterpene chemicals. Diacetoxyscirpenol (DAS), one of the most toxic type A trichothecenes, is considered [...] Read more.
The trichothecene mycotoxins contaminate cereal grains and have been related to alimentary toxicosis resulted in emetic response. This family of mycotoxins comprises type A to D groups of toxic sesquiterpene chemicals. Diacetoxyscirpenol (DAS), one of the most toxic type A trichothecenes, is considered to be a potential risk for human and animal health by the European Food Safety Authority. Other type A trichothecenes, T-2 toxin and HT-2 toxin, as well as type B trichothecene deoxynivalenol (DON), have been previously demonstrated to induce emetic response in the mink, and this response has been associated with the plasma elevation of neurotransmitters peptide YY (PYY) and serotonin (5-hydroxytryptamine, 5-HT). However, it is found that not all the type A and type B trichothecenes have the capacity to induce PYY and 5-HT. It is necessary to identify the roles of these two emetogenic mediators on DAS-induced emesis. The goal of this study was to determine the emetic effect of DAS and relate this effect to PYY and 5-HT, using a mink bioassay. Briefly, minks were fasted one day before experiment and given DAS by intraperitoneally and orally dosing on the experiment day. Then, emetic episodes were calculated and blood collection was employed for PYY and 5-HT test. DAS elicited robust emetic responses that corresponded to upraised PYY and 5-HT. Blocking the neuropeptide Y2 receptor (NPY2R) diminished emesis induction by PYY and DAS. The serotonin 3 receptor (5-HT3R) inhibitor granisetron totally restrained the induction of emesis by serotonin and DAS. In conclusion, our findings demonstrate that PYY and 5-HT have critical roles in DAS-induced emetic response. Full article
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