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Open AccessArticle

Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin

1
Department for Experimental Toxicology and Pharmacology, National Poison Control Centre, Military Medical Academy, 11000 Belgrade, Serbia
2
Department of Pharmacological Science, Medical Faculty of the Military Medical Academy, University of Defence, 11000 Belgrade, Serbia
3
Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanského 62 500 03 Hradec Králové, Czech Republic
4
Department of Analytical Chemistry, Faculty of Chemistry, University of Belgrade, 11158 Belgrade, Serbia
5
Department for Physiology, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia
6
Institute for Poultry Disease, Faculty of Veterinary Medicine, University of Belgrade, 11000 Belgrade, Serbia
7
Special Police Unit, Police Department of the City of Belgrade, Ministry of Interior, 11030 Belgrade, Serbia
8
College of Life Science, Yangtze University, Jingzhou, Hubei 434023, China
*
Authors to whom correspondence should be addressed.
Equal contribution.
Toxins 2020, 12(10), 643; https://doi.org/10.3390/toxins12100643
Received: 31 August 2020 / Revised: 30 September 2020 / Accepted: 2 October 2020 / Published: 5 October 2020
In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells. View Full-Text
Keywords: T-2 toxin; adsorbents; rats; antidote T-2 toxin; adsorbents; rats; antidote
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Jaćević, V.; Dumanović, J.; Lazarević, M.; Nepovimova, E.; Resanović, R.; Milovanović, Z.; Wu, Q.; Kuča, K. Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. Toxins 2020, 12, 643.

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