Venom and Neurology: From Molecular Mechanism to Clinical Medicine

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1023

Special Issue Editor


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Guest Editor
Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410013, China
Interests: spider peptide toxins; voltage-gated sodium channels; voltage-gated calcium channels; peptide toxin; pharmacology; ion channels

Special Issue Information

Dear Colleagues,

Animal venoms represent a rich source of bioactive molecules that have evolved to precisely interact with specific neurological targets, such as ion channels and receptors. This intricate interplay makes venoms powerful tools for probing the fundamental mechanisms of neurological function and dysfunction. This Special Issue, "Venom and Neurology: From Molecular Mechanism to Clinical Medicine", aims to bridge the gap between basic toxin research and clinical applications. We invite contributions that explore the neuropharmacology of venom components, their mechanisms of action at a molecular and cellular level, and their potential as lead compounds for diagnosing and treating neurological disorders. Topics of interest include, but are not limited to, the use of neurotoxins to study channelopathies, the development of novel neurotherapeutics (e.g., analgesics, anticonvulsants) inspired by venom peptides, and the clinical management of neurotoxic envenomations. By bringing together research from these interconnected fields, this Special Issue seeks to highlight the immense potential of venoms in advancing neurological science and medicine.

Prof. Dr. Meichun Deng
Guest Editor

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Keywords

  • neurotoxins
  • ion channels
  • neurological disorders
  • venom peptides
  • channelopathies
  • therapeutic applications
  • pain
  • envenomation
  • drug discovery
  • neuroscience

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Published Papers (1 paper)

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Research

19 pages, 6901 KB  
Article
Molecular Basis of the Inhibition of Voltage-Gated Potassium Channel Kv1.1 by Chinese Tarantula Peptide Huwentoxin-XI
by Xuan Luo, Yuan Yin, Fenghua Wang, Xinyu Li, Shujun Wang, Yumei Yang, Chunbing Zheng, Jing Liu and Meichun Deng
Toxins 2026, 18(3), 124; https://doi.org/10.3390/toxins18030124 - 1 Mar 2026
Viewed by 758
Abstract
Huwentoxin-XI (HWTX-XI) is a 55-amino acid peptide belonging to the family of spider Kuntiz-type toxins (KTTs), isolated from the venom of the Chinese tarantula Cyriopagopus schmidti. Under whole-cell voltage-clamp conditions, HWTX-XI was found to block Kv1.1 potassium channels but had no effect [...] Read more.
Huwentoxin-XI (HWTX-XI) is a 55-amino acid peptide belonging to the family of spider Kuntiz-type toxins (KTTs), isolated from the venom of the Chinese tarantula Cyriopagopus schmidti. Under whole-cell voltage-clamp conditions, HWTX-XI was found to block Kv1.1 potassium channels but had no effect on other potassium channel subunits (Kv1.4, Kv2.1, Kv3.1 and Kv4.2), sodium channels or calcium channels. In the present study, it was found that the substitution of Tyr379 by the valine in the filter region significantly decreased the affinity of toxin HWTX-XI by about 90-fold, indicating that the Kv1.1 filter region is a critical determinant of HWTX-XI potassium channel activity. After intrathecal or intraplantar injections, HWTX-XI decreased the mechanical nociceptive threshold (hyperalgesia) for a long-lasting period. HWTX-XI also significantly increased the firing frequency in mouse DRG neurons. The novel function of HWTX-XI makes it a new tool for studying the relationship between spider toxins and Kv1.1 channels and suggests that Kv1.1 channels might be a novel potential target for preventing and/or treating neuropathic pain. Full article
(This article belongs to the Special Issue Venom and Neurology: From Molecular Mechanism to Clinical Medicine)
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