Prevention and Remediation of Mycotoxins

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 877

Editor


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Guest Editor
Aix Marseille Univ, CNRS, Centrale Marseille, iSM2, 13013 Marseille, France
Interests: biochemistry; nutrition; food science; technology and safety; sustainability

Special Issue Information

Dear Colleagues,

The exposure of animals and humans to mycotoxins is a serious health and economic problem. At least one fourth of plant-based foods are contaminated and the situation is worsening due to the rapid increase in climate change and the consequent expansion of mycotoxin-producing fungi.

The Knowledge about these molecules is also advancing rapidly, particularly regarding the limits of quantification and characterization of metabolites and the modes of action of these molecules. The improvement in quantification levels reveals, in particular, that the proportion of infected crops and the associated health risks are greater than previously thought, especially with regard to mycotoxins, which exhibit endocrine effects. There is no shortage of means of prevention and remediation, especially alternative tools to fungicides based on natural molecules or microorganisms, or appropriate practices.

This remains insufficient, however and it is therefore time to intensify efforts to find ways to reduce mycotoxin levels in food as much as possible. To achieve this, rational, sustainable and feasible strategies must be adopted. These strategies must also include clear and convincing communication plans addressed to all stakeholders—in other words, Citizens—regarding the health risks associated with mycotoxin exposure and the available remediation methods.

This issue of Toxins is dedicated to preventing the formation of mycotoxins throughout the food chain: before and after harvest, during storage and transport, before or after processing, if any, and during the distribution of food products. The Issue will publish the results of fundamental research in this field, in the form of research articles or general reviews, as well as conceptual or operational manuscripts.

Dr. El Hassan Ajandouz
Guest Editor

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Keywords

  • mycotoxin
  • prevention
  • remediation
  • mitigation
  • food safety and security
  • sustainability

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Published Papers (1 paper)

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Research

15 pages, 1359 KB  
Article
Effects of the Temperature and Limosilactobacillus fermentum Co-Inoculation on the Expression of AFB1-Synthesis Genes and the Level of Toxin Produced by Aspergillus flavus Zt41 in Corn Silage
by Szilamér Ferenczi, Ildikó Bata-Vidács, Judit Kosztik, István Nagy, Katalin Inotai, Olívia Csernus, Natália Szeőcs, Zsuzsanna Szőke, Mónika Varga, András Szekeres and József Kukolya
Toxins 2026, 18(6), 254; https://doi.org/10.3390/toxins18060254 - 4 Jun 2026
Viewed by 433
Abstract
Aflatoxin B1 (AFB1), a highly potent Group 1 human carcinogen produced by Aspergillus flavus (A. flavus), poses a significant contamination risk to corn silage, a threat that is further intensified by rising global temperatures. This study aimed to characterize the combined [...] Read more.
Aflatoxin B1 (AFB1), a highly potent Group 1 human carcinogen produced by Aspergillus flavus (A. flavus), poses a significant contamination risk to corn silage, a threat that is further intensified by rising global temperatures. This study aimed to characterize the combined effects of temperature and co-inoculation with the lactic acid bacterium Limosilactobacillus fermentum (L. fermentum) on AFB1 production and the expression of key biosynthetic genes in A. flavus colonizing corn silage. Corn silage was incubated at 20 °C, 30 °C, and 37 °C with and without L. fermentum. Using qRT-PCR and HPLC, we found that elevated temperatures, particularly 37 °C, strongly induced the expression of the aflatoxin biosynthetic cluster, including the regulatory gene aflR and structural genes such as omtA and ordA. Co-inoculation with L. fermentum consistently reduced in the final AFB1 concentration by approximately 50–60% at all three temperatures. Molecular analysis revealed that this reduction was associated with transcriptional repression at 30 °C and 37 °C. L. fermentum consistently and markedly down-regulated the expression of aflR and all structural genes. A particularly pronounced suppression was observed for the late-pathway gene ordA at 30 °C. These findings provide molecular evidence supporting the incorporation of selected L. fermentum strains into silage inoculant formulations to mitigate the AFB1 risk under high-temperature conditions. Full article
(This article belongs to the Special Issue Prevention and Remediation of Mycotoxins)
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