Recent Advances and Future Perspectives on Genotoxicity of Toxins
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: 31 December 2025 | Viewed by 7
Special Issue Editor
Interests: genome profiling of carcinogen resistance; DNA recombination and repair in budding yeast; deoxynucleotide imbalance and genome instability
Special Issue Information
Dear Colleagues,
Natural toxins, such as mycotoxins, microcystins, phytochemicals, and colibactins, are well known for their acute cytotoxicity, but their genotoxic effects are still being elucidated. Understanding such genotoxic effects is particularly relevant considering the predicted increase in toxin exposure due to weather extremes. The purpose of this Special Issue is to explore the lesser-known genotoxic effects of natural toxins and subsequent carcinogenic, teratogenic, and developmental pathologies. While many toxins are genotoxic per se, others require metabolic activation to become potent genotoxins. The metabolic activation of such genotoxins, in turn, may be highly variable among human populations. Advances in high-throughput sequencing and DNA barcoding have facilitated the identification of genes that confer resistance to natural toxins. The cellular response to natural toxins has further been elucidated by multiple transcriptomic, proteomic, and metabolomic studies. Such studies have utilized model organisms, including yeast, zebra fish, and daphnia, as well as metabolically active mammalian cell lines. This Special Issue aims to serve as an excellent compilation of articles describing the diverse genotoxic effects of multiple toxins.
Dr. Michael Fasullo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mycotoxins
- aristolochic acid
- psoralens
- genome profiling
- transcriptomics
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