Dear Colleagues,

High-throughput technologies are widely used as systemic approaches to explore differences in expressions of thousands of genes or metabolites for both biological and genomics systems. The proper and full utilization of these data from multi-omics would therefore accelerate the identification of important disease biomarkers as well as facilitate the development of improved molecular signatures. For instance, genes are usually considered to represent potential disease biomarkers when they show differential overexpression in a particular cancer. Meanwhile, the gut microbiome pattern reflects the pathophysiological condition of the body, and metagenomics serves as a powerful tool to analyze the core bacterial properties. Bidirectional communication between the gut microbiota and the liver is conducted by the signals generated from genetic or dietary factors. Therefore, it is also well recognized that many upregulated and downregulated genes or metabolites are associated with disease development. Although the data from these analyses need to be confirmed via further detailed studies, it nonetheless helps to somehow foresee the trend of information for disease to develop. However, the bioinformatics data accompanied by validation experiments are also sought after. This Special Issue of Separations entitled “Multi-Omics and Bioinformatics Approach to Identify Novel Disease Biomarkers” seeks papers on the following topics:

• Metagenomics, metabolomics, microbiome, proteomics, genomics, epigenomics, transcriptomics;
• Systems biology and multimodal analysis, high throughput screening via mass spectrometry, microarray, RNAi, Next-Generation Sequencing (NGS);
• Drug discovery and disease biomarkers, natural compounds, Traditional Chinese Medicine (TCM), Complementary and Alternative Medicine (CAM).

Dr. Chihyang Wang
Dr. Wei-Jan Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Metagenomics
• Metabolomics
• Microbiome
• Proteomics
• Genomics
• Epigenomics
• Transcriptomics
• Systems biology and multimodal analysis
• High throughput screening via mass spectrometry
• Microarray, RNAi, Next-Generation Sequencing (NGS)
• Drug discovery and disease biomarkers
• Natural compounds, Traditional Chinese Medicine (TCM)
• Complementary and Alternative Medicine (CAM)