Special Issue "Multi-Omics and Bioinformatics Approach to Identify Novel Disease Biomarker"

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (10 April 2022) | Viewed by 753

Special Issue Editors

Dr. Chih-Yang Wang
E-Mail Website
Guest Editor
Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science, Taipei Medical University, Taipei 11031, Taiwan
Interests: bioinformatics; biochemistry; cancer metabolism; traditional Chinese medicine; herbal genomics; pharmacology
Special Issues, Collections and Topics in MDPI journals
Dr. Wei-Jan Wang
E-Mail Website
Co-Guest Editor
Research Center for Cancer Biology, Department of Biological Science and Technology, China Medical University, Taichung 40604, Taiwan
Interests: cancer; molecular mechanism; drug resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

High-throughput technologies are widely used as systemic approaches to explore differences in expressions of thousands of genes or metabolites for both biological and genomics systems. The proper and full utilization of these data from multi-omics would therefore accelerate the identification of important disease biomarkers as well as facilitate the development of improved molecular signatures. For instance, genes are usually considered to represent potential disease biomarkers when they show differential overexpression in a particular cancer. Meanwhile, the gut microbiome pattern reflects the pathophysiological condition of the body, and metagenomics serves as a powerful tool to analyze the core bacterial properties. Bidirectional communication between the gut microbiota and the liver is conducted by the signals generated from genetic or dietary factors. Therefore, it is also well recognized that many upregulated and downregulated genes or metabolites are associated with disease development. Although the data from these analyses need to be confirmed via further detailed studies, it nonetheless helps to somehow foresee the trend of information for disease to develop. However, the bioinformatics data accompanied by validation experiments are also sought after. This Special Issue of Separations entitled “Multi-Omics and Bioinformatics Approach to Identify Novel Disease Biomarkers” seeks papers on the following topics:

  • Metagenomics, metabolomics, microbiome, proteomics, genomics, epigenomics, transcriptomics;
  • Systems biology and multimodal analysis, high throughput screening via mass spectrometry, microarray, RNAi, Next-Generation Sequencing (NGS);
  • Drug discovery and disease biomarkers, natural compounds, Traditional Chinese Medicine (TCM), Complementary and Alternative Medicine (CAM).

Dr. Chihyang Wang
Dr. Wei-Jan Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metagenomics
  • Metabolomics
  • Microbiome
  • Proteomics
  • Genomics
  • Epigenomics
  • Transcriptomics
  • Systems biology and multimodal analysis
  • High throughput screening via mass spectrometry
  • Microarray, RNAi, Next-Generation Sequencing (NGS)
  • Drug discovery and disease biomarkers
  • Natural compounds, Traditional Chinese Medicine (TCM)
  • Complementary and Alternative Medicine (CAM)

Published Papers (1 paper)

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Research

Article
Role of Extracts Obtained from Rainbow Trout and Sole Side Streams by Accelerated Solvent Extraction and Pulsed Electric Fields on Modulating Bacterial and Anti-Inflammatory Activities
Separations 2021, 8(10), 187; https://doi.org/10.3390/separations8100187 - 14 Oct 2021
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Abstract
In this study, accelerated solvent extraction (ASE) and pulsed electric field (PEF) were used as innovative approaches to recover extracts from rainbow trout and sole side streams rich in high-added-value compounds. Then, after aseptic filtration, the impact of the obtained extracts on bacterial [...] Read more.
In this study, accelerated solvent extraction (ASE) and pulsed electric field (PEF) were used as innovative approaches to recover extracts from rainbow trout and sole side streams rich in high-added-value compounds. Then, after aseptic filtration, the impact of the obtained extracts on bacterial growth and anti-inflammatory potential was evaluated. Moreover, the protein content and the total antioxidant capacity of the samples were determined. The results showed that some extracts could inhibit the growth of pathogenic bacteria, including the ASE rainbow trout skin and the PEF sole viscera extracts, which showed significant antibacterial activity on Staphylococcus aureus. The PEF sole viscera extract also showed an inhibitory effect on the growth of Salmonella. In addition, some extracts promoted probiotic bacteria growth. For example, the PEF rainbow trout head and skin extracts promoted Lactobacillus casei growth, while the ASE rainbow trout head and skin extracts promoted Bifidobacterium lactis growth. In addition, some samples, such as the ASE rainbow trout viscera and the PEF sole skin extracts had interesting anti-inflammatory properties. Therefore, the use of ASE and PEF can be considered as useful strategies to recover antimicrobial, prebiotic and anti-inflammatory extracts from rainbow trout and sole side streams, although it is necessary to evaluate each specific side stream. Full article
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