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Special Issue "Advances in Optical Sensing for Biomedical and Biotechnological Applications"

A special issue of Sensors (ISSN 1424-8220).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editors

Guest Editor
Prof. Maria Lepore

Dipartimento di Medicina Sperimentale, Università della Campania "Luigi Vanvitelli", Via S.M.Costantinopoli 16, 80138 Napoli, Italy
Website | E-Mail
Phone: 081-566--5839
Fax: 081-5667500
Interests: fluorescence optical methods; vibrational spectroscopies; enzymatic optical biosensing; biomedical applications; two-photon microscopy
Guest Editor
Prof. Ines Delfino

Dipartimento di Scienze Ecologiche e Biologiche, Università della Tuscia, 01100 Viterbo, Italy
Website | E-Mail
Interests: ultrafast optical spectroscopy; Raman and SERS techniques; light scattering methods; multivariate data analysis, optical biosensing

Special Issue Information

Dear Colleagues,

Optical methods are non-invasive tools that have allowed the development of a large number of sensors for quantitatively and qualitatively determining the components of analytes of interest in many fields of application including pharmaceutical research, medical diagnostics, environmental monitoring, agriculture, industry, food safety and security. In the last years, advances in experimental and data analysis techniques have enabled the development of new sensing schemes and devices characterized by superior working parameters (very low detection limit, high specificity and sensitivity) and innovative applicative approaches. The aim of this special issue is to offer an overview of the recent advances in the use of optical methods for biomedical and biotechnological applications. With this aim, original research papers, as well as review articles, will be published to show the diversity of the new developments in these areas and their wide dissemination in these fields. If you require clarifications, or wish to discuss your submission in advance, we encourage you to contact us. We look forward to and welcome your participation in this Special Issue.

Prof. Maria Lepore
Dr. Ines Delfino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • physical, chemical and biological sensors
  • Raman and SERS sensing
  • SEIRA sensing
  • Sensors based on colorimetry, evanescent wave and infrared spectroscopies
  • light-scattering sensing
  • fluorescence
  • label-free sensing
  • plasmonic based sensors
  • spectral analysis
  • multivariate data analysis
  • chemometrics

Published Papers (1 paper)

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Open AccessArticle A Handheld Real-Time Photoacoustic Imaging System for Animal Neurological Disease Models: From Simulation to Realization
Sensors 2018, 18(11), 4081; https://doi.org/10.3390/s18114081
Received: 25 September 2018 / Revised: 14 November 2018 / Accepted: 19 November 2018 / Published: 21 November 2018
Cited by 1 | PDF Full-text (2983 KB) | HTML Full-text | XML Full-text | Supplementary Files
This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions [...] Read more.
This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1% Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO2), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments. Full article

Graphical abstract

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