Biological In Vitro Models

Dear Colleagues,

Biological testing of medicines and environmental toxins traditionally begins with cell culture and continues with animal experiments, usually in small laboratory rodents. Animal studies, compared to conventional cell culture, have the advantage of more realistic exposure conditions and the ability to evaluate effects on more cell types and on their interaction. Animal experiments are considered the gold standard for biological testing.

Better knowledge of inter-species differences in physiology, particularly regarding the immune system; directives issued by authorities like the European Union to replace animal experimentation; and the development of more physiologically relevant cell culture models will change the currently used tiered testing strategies. It is expected that the role of in silico techniques and cellular models will increase in comparison to animal experiments.

This Special Issue invites submissions on the topic of cellular testing, including but not limited to the comparison between different in vitro models, correlation of in vitro and in vivo models, analytical tools for evaluation of cellular processes, and development of advanced (e.g. dynamic, 3D models, co-culture) in vitro models.

Prof. Eleonore Fröhlich
Guest Editor

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