Proteomes in Drug Development

Dear Colleagues,

In recent years there has been a shift in drug discovery and development from more traditional target-centric approaches towards viewing a drug and its target(s) in a broader biological context earlier in the development process. Drug efficacy, toxicity, and mechanisms of action and resistance are early on being evaluated on the cellular and organismal level using phenotypic screening and systems biology approaches. Furthermore, the transformative power of deep sequencing technologies has reminded us of the necessity of biomarker development for companion diagnostic-supported therapies. Enabled by massive technological advances in instrumentation, methodology, and data analysis over the last decade, mass spectrometry- and antibody array-based proteomic methods have proven to be powerful tools, which provide important global, unbiased and dynamic insight into these aspects. As a consequence, proteomics is these days widely applied to complement biochemical, pharmacological and genomic information.

This Special Issue on "Proteomes in Drug Development" will showcase new developments, highlights and applications of diverse proteomic approaches in the context of drug discovery and development. It will furthermore illustrate how proteomics is making essential contributions to a multi-layered, systems-level view of drug action, toxicity, and resistance, ultimately leading to a better understanding of the engaged biological targets, processes and networks that underlie the complexity of the majority of human diseases.

Dr. Uwe Rix
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.