Proteomic Cancer Biomarkers in Human Biofluids
A special issue of Proteomes (ISSN 2227-7382).
Deadline for manuscript submissions: closed (31 July 2015) | Viewed by 20854
Special Issue Editor
Interests: cancer-specific proteomes; protein biomarkers; tissue-specific biofluids; multianalyte biomarker panels; presymptomatic cancer diagnostics
Special Issue Information
Dear Colleagues,
The National Cancer Institute at the National Institutes of Health defines a biomarker as a “biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease”. Biomarkers can provide molecular signals of the status of a disease as well as provide information for targeted therapeutic interventions. The host response to cancer-specific proteins also provides diagnostic indicators suitable for monitoring tumor burden and the effectiveness of clinical interventions. Biomarkers have been employed to stratify cancer patients to the most effective treatment. Biomarkers for the early detection of cancer must result in a reduction in disease-specific mortality from cancer otherwise the medical community cannot be expected to adopt their use. Researchers now recognize that panels of biomarker analytes rather than single markers will be needed to have sufficient sensitivity and specificity for the presymptomatic detection of cancer. Proteomics studies have shown that there is considerable overlap of protein biomarkers even among unrelated tumors such that additional approaches are needed for tissue specificity.
One solution to the dilemma of specificity is to perform biomarker studies in biofluids other than serum or plasma. Because of the ease of using serum or plasma, most cancer biomarker studies utilize these biofluids. However, using other biofluids physiologically associated with a particular tissue may provide more organ specific tumor biomarkers. With this in mind we have primarily focused this issue on the use of nontraditional biofluids for cancer proteomic screening modalities and secondarily on biomarker proteins other than those secreted from tumor cells because they tend to identify cases with large, late stage tumors. Ideally a biomarker screening panel should identify a specific cancer sufficiently early when treatments can result in an increase in progression-free survival rather than simply a lead-time bias.
Prof. Dr. Michael A. Tainsky
Guest Editor
Manuscript Submission Information
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Keywords
- organ specific tumor biomarkers
- early detection of cancer
- biomarker screening panel
- cancer-specific proteins
- presymptomatic detection of cancer
- biomarkers for targeted therapeutic interventions
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