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Innovations in Hydrogel Design for Pharmaceutical and Medical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Innovation of Polymer Science and Technology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1945

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Jedności 10, 41-200 Sosnowiec, Poland
Interests: drug form technology; new drug carriers; preformulation and formulation studies; manufacturing process of liquid; semisolid and solid dosage forms
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Guest Editor
Faculty of Science and Technology, Jan Długosz University, Al. Armii Krajowej 13/15, 42-200 Czestochowa, Poland
Interests: physical chemistry of condensed phases; multicomponent system

Special Issue Information

Dear Colleagues,

Hydrogels, being polymeric biomaterials, play a significant role in modern pharmacy and medicine. They find use as drug carriers in particular because of their high physical stability, biocompatibility, hydrophilicity, and low sensitization potential. Moreover, their production technology is simple. The continuous growth in our understanding in this area allows for the development of innovative solutions for clinical applications.

This Special Issue aims at advancing research in hydrogel technology, including novel synthesis methods and modifications of already known processes, the physics and physical chemistry of hydrogel materials, and the development of functional hydrogels. We encourage authors to submit research reports aimed at obtaining hydrogel materials for use in pharmaceutical and biomedical engineering. We accept reviews and original papers on newly obtained materials, the development of already-used materials, and their potential applications. Reports of basic, pre-clinical, and clinical studies on innovative hydrogel-based materials of importance for modern pharmacy and medicine are also welcome

Dr. Aneta Ostróżka-Cieślik
Prof. Dr. Wojciech Marczak
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • biomaterials
  • hydrogel technology
  • multifunctional hydrogels
  • drug delivery systems
  • pharmaceutical applications
  • medical applications

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Published Papers (2 papers)

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Research

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21 pages, 5574 KiB  
Article
Pectin/Gellan Gum Hydrogels Loaded with Crocus sativus Tepal Extract for In Situ Modulation of Pro-Inflammatory Pathways Affecting Wound Healing
by Francesco Busto, Caterina Licini, Stefania Cometa, Stefano Liotino, Elisabetta Damiani, Tiziana Bacchetti, Isabelle Kleider, Alessandra La Contana, Monica Mattioli-Belmonte and Elvira De Giglio
Polymers 2025, 17(6), 814; https://doi.org/10.3390/polym17060814 - 20 Mar 2025
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Abstract
Tepals of the Crocus sativus flower constitute the most abundant floral residue during saffron production (350 kg tepals/kg stigmas). Being a natural source of polyphenols with antioxidant properties, they can be reused to create potentially valuable products for pharmaceutical applications, generating a new [...] Read more.
Tepals of the Crocus sativus flower constitute the most abundant floral residue during saffron production (350 kg tepals/kg stigmas). Being a natural source of polyphenols with antioxidant properties, they can be reused to create potentially valuable products for pharmaceutical applications, generating a new income source while reducing agricultural bio-waste. In this work, composite hydrogels based on blends of pectin and gellan gum containing Crocus sativus tepal extract (CSE) have been proposed for the regeneration and healing of cutaneous wounds, exploiting the antioxidant properties of CSE. Various physico-chemical and mechanical characterizations were performed. The skin permeation of CSE was investigated using Franz cell diffusion system. The composite films were cytocompatible and able to counteract the increase in ROS, restore the production of matrix proteins, and favor wound closure. To conclude, CSE-loaded composite films represent a promising strategy to promote the body’s natural healing process. In addition, by reusing saffron tepals, not only can we develop new, sustainable treatments for skin diseases, but we can also reduce agricultural waste. Full article
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Review

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36 pages, 727 KiB  
Review
The Potential of Hydrogel Preparations Containing Plant Materials in Supporting the Treatment of Vaginal and Vulvar Infections—Current State of Knowledge
by Aneta Ostróżka-Cieślik, Monika Michalak, Tomasz Bryś and Marek Kudła
Polymers 2025, 17(4), 470; https://doi.org/10.3390/polym17040470 - 11 Feb 2025
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Abstract
Vaginal hydrogels are a modern alternative to solid (tablets, globules) and other semi-solid forms of medication (ointments, creams) in the control of pathogenic microorganisms in diseases of the female reproductive tract. This review aims to summarize the current state of knowledge regarding the [...] Read more.
Vaginal hydrogels are a modern alternative to solid (tablets, globules) and other semi-solid forms of medication (ointments, creams) in the control of pathogenic microorganisms in diseases of the female reproductive tract. This review aims to summarize the current state of knowledge regarding the efficacy of hydrogels containing plant materials in the treatment of vaginal and vulvar infections. New therapies are essential to address the growing antimicrobial resistance crisis. Google Scholar, Web of Science, Cochrane, and Medline (PubMed) databases were searched. Twenty-five studies were included in the review, including basic, pre-clinical, and clinical studies. The results obtained confirmed the therapeutic potential of plant raw materials embedded in the polymer matrix of hydrogels. However, due to the small number of clinical trials conducted, further research in this area is needed. Full article
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