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Polymers
Special Issues
Biopolymer Coatings in Dental Application
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Biopolymer Coatings in Dental Application

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (5 April 2023) | Viewed by 5570

Special Issue Editors

Dr. Paolo Ghensi

E-Mail Website
Guest Editor
Department of Cellular, Computational and Integrative Biology, University of Trento, 38122 Trento, Italy
Interests: periodontology; implant dentistry; dental implantology; oral surgery; esthetic dentistry; fixed prosthodontics; restorative dentistry; aesthetic dentistry; dental prosthesis; dental materials; anti-biofilm; anti-adhesive; biopolymers
Special Issues, Collections and Topics in MDPI journals
Dr. Francesco Tessarolo

E-Mail Website
Guest Editor
BioTech Center for Biomedical Technologies, Department of Industrial Engineering, Università di Trento, 38123 Trento, Italy
Interests: aging; bacteria; biocompatibility; biological processes; logic microstructures; optical imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mucositis and peri-implantitis are common microbial–biofilm-associated diseases affecting the tissues that surround the dental implant and are a major medical and socioeconomic burden. The treatment of these diseases is arduous and constitutes an important issue in modern clinical practice. Prevention strategies have therefore become extremely important. Numerous scientific studies are currently focused on the development of new methods to prevent bacterial adhesion and peri-implant infection.

Polymers have a wide variety of applications in dentistry due to their improved properties and broad applicability. Non-fouling biopolymer coatings and anti-adhesive/anti-biofilm biopolymers may, as a result, have a positive biological effect on the prevention of peri-implant diseases.

This Special Issue aims to collect research results in this topic. Both original contributions and reviews are welcome.

Dr. Paolo Ghensi
Dr. Francesco Tessarolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • implant dentistry
  • dental materials
  • anti-biofilm
  • anti-adhesive
  • biopolymers

Published Papers (2 papers)

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Research

17 pages, 7664 KiB  
Article
A Bacteria and Cell Repellent Zwitterionic Polymer Coating on Titanium Base Substrates towards Smart Implant Devices
by Mona Es-Souni, Martha Es-Souni, Hamzah Bakhti, Aydin Gülses, Helge Fischer-Brandies, Yahya Açil, Jörg Wiltfang and Christian Flörke
Polymers 2021, 13(15), 2472; https://doi.org/10.3390/polym13152472 - 27 Jul 2021
Cited by 7 | Viewed by 2361
Abstract
Biofouling and biofilm formation on implant surfaces are serious issues that more than often lead to inflammatory reactions and the necessity of lengthy post-operation treatments or the removal of the implant, thus entailing a protracted healing process. This issue may be tackled with [...] Read more.
Biofouling and biofilm formation on implant surfaces are serious issues that more than often lead to inflammatory reactions and the necessity of lengthy post-operation treatments or the removal of the implant, thus entailing a protracted healing process. This issue may be tackled with a biocompatible polymeric coating that at the same time prevents biofouling. In this work, oxygen plasma-activated silanized titanium substrates are coated with poly(sulfobetaine methacrylate), a zwitterionic antibiofouling polymer, using photopolymerization. The characterization of polymer films includes FT-IR, AFM, and adhesion strength measurements, where adhesion strength is analyzed using a cylindrical flat punch indenter and water contact angle (WCA) measurements. Both cytotoxicity analysis with primary human fibroblasts and fluorescence microscopy with fibroblasts and plaque bacteria are also performed is this work, with each procedure including seeding on coated and control surfaces. The film morphology obtained by the AFM shows a fine structure akin to nanoropes. The coatings can resist ultrasonic and sterilization treatments. The adhesion strength properties substantially increase when the films are soaked in 0.51 M of NaCl prior to testing when compared to deionized water. The coatings are superhydrophilic with a WCA of 10° that increases to 15° after dry aging. The viability of fibroblasts in the presence of coated substrates is comparable to that of bare titanium. When in direct contact with fibroblasts or bacteria, marginal adhesion for both species occurs on coating imperfections. Because photopolymerization can easily be adapted to surface patterning, smart devices that promote both osseointegration (in non-coated areas) and prevent cell overgrowth and biofilm formation (in coated areas) demonstrate practical potential. Full article
(This article belongs to the Special Issue Biopolymer Coatings in Dental Application)
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18 pages, 1512 KiB  
Article
Counter-Acting Candida albicans-Staphylococcus aureus Mixed Biofilm on Titanium Implants Using Microbial Biosurfactants
by Erica Tambone, Alice Marchetti, Chiara Ceresa, Federico Piccoli, Adriano Anesi, Giandomenico Nollo, Iole Caola, Michela Bosetti, Letizia Fracchia, Paolo Ghensi and Francesco Tessarolo
Polymers 2021, 13(15), 2420; https://doi.org/10.3390/polym13152420 - 23 Jul 2021
Cited by 13 | Viewed by 2415
Abstract
This study aimed to grow a fungal-bacterial mixed biofilm on medical-grade titanium and assess the ability of the biosurfactant R89 (R89BS) coating to inhibit biofilm formation. Coated titanium discs (TDs) were obtained by physical absorption of R89BS. Candida albicans-Staphylococcus aureus biofilm [...] Read more.
This study aimed to grow a fungal-bacterial mixed biofilm on medical-grade titanium and assess the ability of the biosurfactant R89 (R89BS) coating to inhibit biofilm formation. Coated titanium discs (TDs) were obtained by physical absorption of R89BS. Candida albicans-Staphylococcus aureus biofilm on TDs was grown in Yeast Nitrogen Base, supplemented with dextrose and fetal bovine serum, renewing growth medium every 24 h and incubating at 37 °C under agitation. The anti-biofilm activity was evaluated by quantifying total biomass, microbial metabolic activity and microbial viability at 24, 48, and 72 h on coated and uncoated TDs. Scanning electron microscopy was used to evaluate biofilm architecture. R89BS cytotoxicity on human primary osteoblasts was assayed on solutions at concentrations from 0 to 200 μg/mL and using eluates from coated TDs. Mixed biofilm was significantly inhibited by R89BS coating, with similar effects on biofilm biomass, cell metabolic activity and cell viability. A biofilm inhibition >90% was observed at 24 h. A lower but significant inhibition was still present at 48 h of incubation. Viability tests on primary osteoblasts showed no cytotoxicity of coated TDs. R89BS coating was effective in reducing C. albicans-S. aureus mixed biofilm on titanium surfaces and is a promising strategy to prevent dental implants microbial colonization. Full article
(This article belongs to the Special Issue Biopolymer Coatings in Dental Application)
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