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Applications of Polymer Biomedical Materials in Medicine and Dentistry

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 8691

Special Issue Editor


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Guest Editor
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
Interests: dentistry; materials science; polymeric materials; ceramic materials; adhesive dentistry; fatigue and fracture analysis; dental materials; prosthodontics
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Special Issue Information

Dear Colleagues,

In recent years, polymer biomedical materials have attracted increasing attention, especially in the fields of medicine and dentistry. These versatile materials have a wide range of applications, from implants and prosthetics to drug delivery systems, making them invaluable in driving modern healthcare solutions. Many studies have examined their interfacial properties, adhesive bonding, physicochemical and mechanical performance, and biocompatibility, contributing to the rapidly growing body of literature.

The desirable properties of high-performance polymer biomedical materials, such as their mechanical strength, chemical resistance, and radiolucency, make them an attractive alternative to traditional materials in medical and dental applications. Recent research has highlighted exciting advancements, including surface modification techniques that enhance bioactivity, fiber reinforcement to improve mechanical performance, and the integration of 3D printing technologies, artificial intelligence, or big data for customized, patient-specific solutions. Furthermore, the potential of polymer biomedical materials in controlled drug delivery has opened innovative pathways, further expanding their utility in clinical practice in medicine and dentistry.

Given these rapid developments, this Special Issue aims to present high-quality research showcasing recent advances in polymeric biomedical materials, with a special focus on their applications in medicine and dentistry.

Dr. Tzu-Yu Peng
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyetheretherketone
  • high-performance polymers
  • surface modification
  • adhesive bonding
  • physicochemical properties
  • drug delivery
  • biological response
  • additive manufacturing
  • CAD/CAM
  • digital workflow
  • artificial intelligence
  • big data

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Published Papers (3 papers)

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Research

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13 pages, 3906 KB  
Article
Influence of Post-Washing Time and Build Orientation on Mechanical Properties and Biocompatibility of Additively Manufactured Permanent Dental Resin Material
by Pei-Wen Peng, Jia-Syuan Chou, Le-Xin Chen, Po-En Chuang, Hidekazu Takahashi, Min-Chieh Hsieh and Wei-Fang Lee
Polymers 2025, 17(19), 2694; https://doi.org/10.3390/polym17192694 - 5 Oct 2025
Viewed by 869
Abstract
Background: Digital light processing (DLP) is widely used in permanent dental restorations for its precision and efficiency, yet the effects of build orientation and post-washing time on resin properties remain unclear. This study aims to investigate the factors that impact the performance and [...] Read more.
Background: Digital light processing (DLP) is widely used in permanent dental restorations for its precision and efficiency, yet the effects of build orientation and post-washing time on resin properties remain unclear. This study aims to investigate the factors that impact the performance and biocompatibility of DLP-printed dental resins. Methods: Specimens were additively manufactured using permanent dental resin at 0°, 15°, and 90° orientations and post-washed for 90, 120, or 150 s. Evaluated properties included dimensional accuracy, hardness, flexural strength and modulus, degree of conversion, water sorption/solubility, and cytotoxicity. Results: Build orientation and post-washing time significantly affected dimensional accuracy, with thickness showing the least deviation. Flexural strength (p < 0.001) and modulus (p < 0.01) were highest at the 0° orientation. Post-washing for 90 s led to the greatest water absorption, while solubility remained unaffected. Cell viability increased with longer post-washing times, peaking at 150 s, with significant effects observed on days 5 and 7 (p < 0.05). Conclusions: Build orientation significantly affected dimensional accuracy and flexural strength, while post-washing time had minimal impact on physical properties. Notably, extended post-washing improved cell viability and reduced cytotoxicity, indicating its potential to enhance the clinical biocompatibility of DLP-fabricated dental resin. Full article
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16 pages, 7959 KB  
Article
Synergistic Effect of Strontium Doping and Surfactant Addition in Mesoporous Bioactive Glass for Enhanced Osteogenic Bioactivity and Advanced Bone Regeneration
by Ya-Yi Chen, Tien-Li Ma, Pei-Jung Chang, Yuh-Jing Chiou, Wei-Min Chang, Ci-Fen Weng, Chin-Yi Chen, Yu-Kang Chang and Chung-Kwei Lin
Polymers 2025, 17(2), 187; https://doi.org/10.3390/polym17020187 - 14 Jan 2025
Cited by 4 | Viewed by 2016
Abstract
Mesoporous bioactive glass (MBG) is an advanced biomaterial widely recognized for its application in bone regenerative engineering. This study synthesized an MBG powder (80 mol% SiO2, 5 mol% P2O5, and 15 mol% CaO) using a facile sol-gel [...] Read more.
Mesoporous bioactive glass (MBG) is an advanced biomaterial widely recognized for its application in bone regenerative engineering. This study synthesized an MBG powder (80 mol% SiO2, 5 mol% P2O5, and 15 mol% CaO) using a facile sol-gel method with the non-ionic surfactant Pluronic® P123, which acted as a pore-forming agent. MBGs form bioactive surfaces that facilitate HA formation, and the presence of Pluronic® P123 increases the surface area and promotes HA nucleation. Various percentages of strontium (Sr) doping were examined to improve bioreactivity, biological response, and bone formation, with 3SMBG (3 mol% Sr) showing the highest specific surface area. In vitro biocompatibility tests revealed HA formation on all glass surfaces after immersion in simulated body fluid (SBF), indicated by sheet-like HA morphologies, the presence of PO43− and CO32− functional groups, and the amorphous structure along with SrCO3 crystalline phases corresponding to HA and Sr-HA structures. Sr doping resulted in delayed initial degradation and sustained release of Sr2+, achieving over 95% cell viability. Surfactant-induced mesoporous structure and Sr incorporation synergistically enhance osteocyte induction and formation in vitro. These findings suggest that Sr-doped MBG, particularly with P123-assisted Sr/Ca substitution, optimizes the material’s properties for advanced bone regenerative applications. Full article
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Review

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20 pages, 336 KB  
Review
Tooth-Whitening Agents and Polymer-Based Carriers: Efficacy, Safety, and Clinical Perspectives
by Pin-Yu Lin, Li-Nai Chen, Chien-Fu Tseng, Yi-Shao Chen, Hung-Yu Lin, Thi Thuy Tien Vo, Tzu-Yu Peng and I-Ta Lee
Polymers 2025, 17(18), 2545; https://doi.org/10.3390/polym17182545 - 20 Sep 2025
Viewed by 2664
Abstract
Tooth whitening is increasingly sought in both clinical and home settings, raising concerns about the efficacy and safety of various whitening agents and their delivery systems. This narrative review compares the whitening performance and biocompatibility of active ingredients, including hydrogen peroxide, carbamide peroxide, [...] Read more.
Tooth whitening is increasingly sought in both clinical and home settings, raising concerns about the efficacy and safety of various whitening agents and their delivery systems. This narrative review compares the whitening performance and biocompatibility of active ingredients, including hydrogen peroxide, carbamide peroxide, activated charcoal, sodium bicarbonate, fluoride compounds, and blue covarine, with particular emphasis on the role of polymer-based carriers in formulation strategies. Hydrogen peroxide and carbamide peroxide remain the most effective agents for intrinsic whitening, but are associated with risks of enamel surface alterations, microhardness reduction, and potential cytotoxicity, particularly at higher concentrations. Sodium bicarbonate provides moderate whitening effects through extrinsic stain removal, while fluoride compounds play a supportive role by reducing demineralization and tooth sensitivity, thereby preserving enamel integrity. These properties make them valuable adjuncts or alternatives for patients with high sensitivity risks. Blue covarine offers immediate optical effects without inducing intrinsic color changes, whereas activated charcoal poses risks of enamel abrasion and surface roughness with limited long-term efficacy. Polymer-based carriers such as Carbopol gels, polyvinylpyrrolidone, and hydroxypropyl methylcellulose are incorporated into whitening formulations to improve viscosity, adhesion, and modulate the release of active ingredients. These polymers might help minimize diffusion of bleaching agents into deeper dental tissues, potentially reducing cytotoxic effects, and may improve handling characteristics. However, dedicated studies evaluating the unique advantages of polymers in different whitening systems remain limited. A comprehensive understanding of both the active ingredients and delivery technologies is critical to balancing esthetic outcomes with long-term oral health. From a clinical perspective, polymer-based carriers might contribute to reducing whitening-related tooth sensitivity, improving patient comfort, and providing more predictable treatment outcomes. Continued research is needed to clarify optimal formulations and application protocols, ensuring safer and more effective tooth-whitening practices in both clinical and home-use scenarios. Full article
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