Unravelling the Medicinal Phytochemistry of Plants in Metabolic and Vascular Diseases and the Associated Oxidative and Inflammatory Responses

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1068

Special Issue Editors


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Guest Editor
Centre for Quality of Health and Living, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein 9300, South Africa
Interests: functional food; diabetes; oxidative stress; medicinal plant
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Guest Editor
Department of Microbiology, School of Life Sciences, University of KwaZulu-Natal, Durban 4000, South Africa
Interests: functional food; toxicology; metabolic diseases; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic and vascular diseases are among the leading non-communicable diseases that compromise the health and wellbeing of people due to their high morbidity and mortality. Epidemiological studies have shown that many metabolic and vascular diseases can co-exist because they often share underlying risk factors, which can worsen the disease conditions. Moreover, oxidative stress has been implicated as a common denominator in the development, progression and complications of metabolic and vascular diseases. Medicinal plants have often been documented as potent treatment alternatives and/or complementary therapeutic agents for many diseases, including metabolic and vascular impairments. This has been linked to their phytochemical constituents, which have diverse pharmacological profiles, including antioxidant capacity. However, it is imperative to understand the pharmacological contributions and medicinal phytochemistries of the phytoconstituents in medicinal plants, as this could encourage the more effective use of medicinal plants in the management of metabolic and vascular diseases.

This Special Issue will compile original high-quality research publications that present experimental and clinical data on the pharmacological properties of medicinal plants in metabolic and vascular diseases and associated oxidative and inflammatory responses. This collection will include studies involving the bioassay-guided recovery and characterization of possible pharmacological isolates, as well as the possible underlying bioactivity–structure relationship, which will provide insights into the medicinal phytochemistries of plants. This collection will also accommodate well-written review articles containing novel interpretations of existing and current scientific knowledge to provide greater insights into the pharmacological phytochemistries of medicinal plants used in metabolic and vascular disease treatment.

Dr. Chika Ifeanyi Chukwuma
Dr. Ochuko Lucky L. Erukainure
Guest Editors

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Keywords

  • phytochemicals
  • pharmacological action
  • oxidative stress
  • metabolic diseases
  • vascular diseases

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Published Papers (1 paper)

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Review

27 pages, 1747 KiB  
Review
Role of Quercetin in Diabetic Cardiomyopathy
by Nor Hidayah Mustafa, Hawa Nordin Siti and Yusof Kamisah
Plants 2025, 14(1), 25; https://doi.org/10.3390/plants14010025 - 25 Dec 2024
Viewed by 813
Abstract
Diabetic cardiomyopathy is a significant and severe complication of diabetes that affects a large portion of the global population, with its prevalence continuing to rise. Secondary metabolites, including quercetin, have shown promising effects in mitigating the progression of diabetic cardiomyopathy by targeting multiple [...] Read more.
Diabetic cardiomyopathy is a significant and severe complication of diabetes that affects a large portion of the global population, with its prevalence continuing to rise. Secondary metabolites, including quercetin, have shown promising effects in mitigating the progression of diabetic cardiomyopathy by targeting multiple pathological mechanisms, including impaired insulin signaling, glucotoxicity, lipotoxicity, oxidative stress, inflammation, fibrosis, apoptosis, autophagy, mitochondrial dysfunction, cardiac stiffness, and disrupted calcium handling. Addressing these mechanisms is crucial to prevent left ventricular diastolic and systolic dysfunction in advanced stages of diabetic heart disease. Scientific evidence has highlighted the cardioprotective properties of quercetin at both the myocardial and cellular/molecular levels in diabetic models. Therefore, this review aims to present a comprehensive overview of the proposed mechanisms underlying quercetin’s beneficial effects, providing valuable insights that could inform future drug discovery efforts specific to diabetic cardiomyopathy. Full article
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