Plant-Derived Bioactive Compound Research

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 740

Special Issue Editors


E-Mail Website
Guest Editor
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi 274-8510, Japan
Interests: plant extracts; new plant-derived compounds; new drug candidates
Special Issues, Collections and Topics in MDPI journals
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Interests: meliaceae; phragmalin; chisocheton

Special Issue Information

Dear Colleagues,

Plants have long been a rich source of bioactive compounds with significant impacts on human health, agriculture, and industry. Plant-derived natural products exhibit remarkable structural diversity and diverse biological activities. Beyond their pharmacological potential, they also play crucial roles in plant defense, adaptation, and ecological interactions. In recent years, advances in analytical chemistry, molecular biology, and synthetic biology have greatly accelerated the exploration of plant metabolites. These advances have enabled the discovery of novel compounds, elucidation of their biosynthetic pathways, and evaluation of their biological functions. Such developments open new opportunities for drug discovery, functional food design, and sustainable agricultural practices. This Special Issue of Plants aims to showcase cutting-edge research on the chemistry, biosynthesis, biological activities, and applications of plant-derived bioactive compounds. We welcome original research articles, reviews, and perspectives that broaden our understanding of these natural products and their potential to address pressing challenges in medicine, nutrition, and the environment.

Prof. Dr. Wei Li
Dr. Jie Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant-derived bioactive compound
  • natural product
  • secondary metabolite
  • biosynthetic pathway
  • biological activity
  • drug discovery
  • functional food

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

11 pages, 427 KB  
Article
Modulation of Plant-Derived Bioactive Phenolic Compounds by Cytokinins in Hypericum amblysepalum Shoot Cultures
by Hilal Surmuş Asan
Plants 2026, 15(7), 1017; https://doi.org/10.3390/plants15071017 - 26 Mar 2026
Viewed by 435
Abstract
Cytokinins are key plant growth regulators that play an important role not only in morphogenesis but also in the regulation of plant-derived bioactive compound production in plant tissue culture systems. In this study, the effects of two cytokinins, 6-benzylaminopurine (BAP) and zeatin (ZEA), [...] Read more.
Cytokinins are key plant growth regulators that play an important role not only in morphogenesis but also in the regulation of plant-derived bioactive compound production in plant tissue culture systems. In this study, the effects of two cytokinins, 6-benzylaminopurine (BAP) and zeatin (ZEA), applied at four concentrations (0.1, 0.25, 0.5, and 1.0 mg L−1), were compared in terms of biomass production and phenolic compound accumulation in shoot cultures of Hypericum amblysepalum Hochst. Both cytokinins significantly enhanced plant growth compared to the control, with the highest dry weight (26.5 ± 8.6 mg DW) and shoot number (11.2 ± 4.4 shoots per explant) recorded in cultures supplemented with 0.1 mg L−1 BAP. In contrast, ZEA was more effective in stimulating the accumulation of secondary metabolites. LC–MS/MS analysis revealed that 0.1 mg L−1 ZEA markedly increased the accumulation of major plant-derived bioactive phenolic compounds, including hypericin, pseudohypericin, chlorogenic acid, rutin, luteolin, hesperidin, luteolin-7-glucoside, and hyperoside, compared to the control. Consistent with these findings, total phenolic content (TPC) and total flavonoid content (TFC) were significantly higher in ZEA-treated cultures, which also exhibited stronger DPPH radical scavenging activity, indicating enhanced antioxidant potential. Overall, these results demonstrate that BAP is more suitable for biomass enhancement, whereas ZEA is more effective in improving the production of bioactive phenolic compounds and antioxidant capacity in H. amblysepalum shoot cultures, highlighting their potential as a sustainable source of valuable plant-derived bioactive metabolites for pharmaceutical applications. Full article
(This article belongs to the Special Issue Plant-Derived Bioactive Compound Research)
Show Figures

Figure 1

Back to TopTop