Special Issue "Preclinical Pharmacokinetics and Bioanalysis"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (16 October 2018)
Today, the development of new drugs is still very time consuming, extremely costly, and suffers from high attrition rates, despite the modern technologies that are widely used in the drug research and development field. One of the biggest bottlenecks in the early phase of drug development is the lack of high-throughput approaches for preclinical pharmacokinetics (PK) screening. Nevertheless, this area has been greatly improved over the past decade because of the revolutionary changes in bioanalytical methods. In particular, with the LC-MS/MS platform, a PK assay for a new drug candidate can be developed in only a few hours, compared with several months as in the past using HPLC-UV/FL methods. Many new preclinical PK screening approaches, including cassette dosing PK, cassette analysis, snapshot PK and rapid PK have been proposed and tested. The progress of these PK technologies could significantly accelerate the process of drug discovery. In addition, they can be widely applied in different stages of drug development to eliminate weak candidates.
This Special Issue on “Preclinical Pharmacokinetics and Bioanalysis” aims to highlight the latest development technologies in this area and to inspire future research in this exciting area.
Dr. Lingzhi Wang
Dr. Xiaoqiang Xiang
Dr. Paul Chi Lui Ho
Manuscript Submission Information
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- Cassette dosing pharmacokinetics
- Cassette analysis
- Snapshot pharmacokinetics
- Rapid pharmacokinetics
- Full pharmacokinetics
- CNS drug pharmacokinetics
- Ocular pharmacokinetics
- Drug Analysis
- Drug metabolism