Novel Research on Physiologically Based Pharmacokinetic Modeling

Dear Colleagues,

Physiologically based pharmacokinetic (PBPK) modeling has rapidly evolved into a core component of model-informed drug development, allowing mechanistic integration of drug properties with human physiology to support evidence-based decision-making. The growing regulatory acceptance of PBPK has accelerated its use in addressing complex clinical questions, including dose optimization in vulnerable populations, prediction of drug–drug interactions, characterization of transporter and enzyme contributions, biowaiver justification, and virtual clinical trial simulation. 

This Special Issue, titled “Novel Research on Physiologically Based Pharmacokinetic Modeling”, highlights cutting-edge applications that demonstrate the expanding impact of PBPK across therapeutic areas and drug modalities. We invite submissions presenting innovative modeling frameworks, integration with pharmacodynamics or disease models, incorporation of in vitro and preclinical data, and quantitative evaluation of mechanistic hypotheses. Research leveraging PBPK to inform pediatric dosing, geriatric considerations, renal or hepatic impairment, genetic variability, long-acting formulations, and complex biologics is particularly welcome. Through original research articles, methodological advances, and comprehensive reviews, this Special Issue aims to provide a platform for novel insights and practical contributions that enhance the reliability, transparency, and translational value of PBPK modeling in drug development and clinical practice.

Dr. Xiaoqiang Xiang
Dr. Qingfeng He
Dr. Yufei Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.