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Open AccessReview

A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

1
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
2
Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore
3
School of Pharmacy, Fudan University, Shanghai 201203, China
4
Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore
5
Department of Pharmacology, Yong Loo Lin School of Medicine, Singapore 117597, Singapore
*
Authors to whom correspondence should be addressed.
Equal contribution.
Pharmaceutics 2018, 10(4), 221; https://doi.org/10.3390/pharmaceutics10040221
Received: 15 October 2018 / Accepted: 5 November 2018 / Published: 8 November 2018
(This article belongs to the Special Issue Preclinical Pharmacokinetics and Bioanalysis)
In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation. View Full-Text
Keywords: LC-MS/MS; rapid; quantification; oncology drugs LC-MS/MS; rapid; quantification; oncology drugs
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Wong, A. .-A.; Xiang, X.; Ong, P.S.; Mitchell, E.Q.Y.; Syn, N.; Wee, I.; Kumar, A.P.; Yong, W.P.; Sethi, G.; Goh, B.C.; Ho, P. .-L.; Wang, L. A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs. Pharmaceutics 2018, 10, 221.

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