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Pharmaceutics
Special Issues
Advanced Materials Science and Technology in Drug Delivery
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Advanced Materials Science and Technology in Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 3496

Special Issue Editors

Dr. Ionela Andreea Neacsu

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Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
Interests: nanomaterials; drug delivery systems; biomimetic materials; biogenic calcium sources; composite scaffolds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ecaterina Andronescu

E-Mail Website
Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 060042 Bucharest, Romania
Interests: materials science; drug delivery systems; nanomaterials; biomaterials; antimicrobial activity; nanoparticle-mediated drug delivery; natural agents in developing efficient wound dressings; hydroxyapatite and bioglass; mesoporous materials

Special Issue Information

Dear Colleagues,

As Guest Editors, we are pleased to invite you to submit your work to this Special Issue on “Advanced Materials Science and Technology in Drug Delivery”. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: advanced synthesis methods and technologies for ceramic and/or composite materials; innovative materials used for drug loading and drug delivery; methods of drug loading, gene delivery; delivery of pharmaceutical compounds (both natural and synthetic); porous materials (carriers) for a controlled/modulated release of bioactive compounds or nanoparticles (zeolites, mesoporous silica, hydroxyapatite, clays, metal-organic framework (MoF)-based materials, organic framework with a porous structure such as COFs, etc.); biological evaluation in terms of antimicrobial, antitumoral or anti-inflammatory effect; biocompatibility; cell-proliferation.

Dr. Ionela Andreea Neacsu
Prof. Dr. Ecaterina Andronescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nano-based drug delivery systems
  • controlled drug release
  • targeted drug delivery systems
  • inorganic nano-carriers for smart drug delivery systems
  • porous carriers
  • gene delivery
  • bio-inspired advanced materials (ceramics, polymers, composites)
  • drug-loaded scaffolds
  • advanced synthesis and processing technology for materials
  • antimicrobial therapies and biofilm modulation
  • anticancer and theranostic nanoparticles

Related Special Issue

Published Papers (2 papers)

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Review

15 pages, 1621 KiB  
Review
Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach
by Elham Saberian, Andrej Jenča, Adriána Petrášová, Hadi Zare-Zardini and Meysam Ebrahimifar
Pharmaceutics 2024, 16(6), 802; https://doi.org/10.3390/pharmaceutics16060802 - 14 Jun 2024
Viewed by 750
Abstract
This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, [...] Read more.
This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin and paclitaxel, have proven effective in inhibiting oral cancer cell proliferation, establishing a promising avenue for site-specific drug delivery. The application of synthetic scaffolds, including Poly Ethylene Glycol (PEG) and poly(lactic-co-glycolic acid) (PLGA), and natural materials, like collagen or silk, in 3D systems has been pivotal for controlled release of therapeutic agents, executing diverse anti-cancer strategies. A key advancement in this field is the advent of smart scaffolds designed for sequential cancer therapy, which strive to refine drug delivery systems, minimizing surgical interventions, accentuating the significance of 3D scaffolds in oral cancer management. These systems, encompassing local drug-coated scaffolds and other scaffold-based platforms, hold the potential to transform oral cancer treatment through precise interventions, yielding improved patient outcomes. Local drug delivery via scaffolds can mitigate systemic side effects typically associated with chemotherapy, such as nausea, alopecia, infections, and gastrointestinal issues. Post-drug release, scaffolds foster a conducive environment for non-cancerous cell growth, adhering and proliferation, demonstrating restorative potential. Strategies for controlled and targeted drug delivery in oral cancer therapy span injectable self-assembling peptide hydrogels, nanocarriers, and dual drug-loaded nanofibrous scaffolds. These systems ensure prolonged release, synergistic effects, and tunable targeting, enhancing drug delivery efficiency while reducing systemic exposure. Smart scaffolds, capable of sequential drug release, transitioning to cell-friendly surfaces, and enabling combinatorial therapy, hold the promise to revolutionize treatment by delivering precise interventions and optimized outcomes. In essence, scaffold-based drug delivery systems, through their varied forms and functionalities, are reshaping oral cancer therapy. They target drug delivery efficiency, diminish side effects, and present avenues for personalization. Challenges like fabrication intricacy, biocompatibility, and scalability call for additional research. Nonetheless, the perspective on scaffold-based systems in oral cancer treatment is optimistic, as ongoing advancements aim to surmount current limitations and fully leverage their potential in cancer therapy. Full article
(This article belongs to the Special Issue Advanced Materials Science and Technology in Drug Delivery)
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18 pages, 809 KiB  
Review
The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment
by Iria Seoane-Viaño, Mariola Seoane-Gigirey, Carlos Bendicho-Lavilla, Luz M. Gigirey, Francisco J. Otero-Espinar and Santiago Seoane-Trigo
Pharmaceutics 2024, 16(6), 769; https://doi.org/10.3390/pharmaceutics16060769 - 5 Jun 2024
Viewed by 904
Abstract
Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on [...] Read more.
Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on various factors, comorbidities, and poor oral health. Prophylaxis and different treatment methods have been widely discussed in recent decades, and surgical and non-surgical techniques present both advantages and disadvantages. In this work, a literature review of different studies on the application of adjuvant treatments, such as local and systemic antibiotics and antiseptic treatments, was conducted. Positive outcomes have been found in the short (up to one year after treatment) and long term (up to ten years after treatment) with combined therapies. However, there is still a need to explore new therapies based on the use of advanced drug delivery systems for the effective treatment of peri-implantitis in the long term and without relapses. Hence, micro- and nanoparticles, implants, and injectable hydrogels, among others, should be considered in future peri-implantitis treatment with the aim of enhancing overall therapy outcomes. Full article
(This article belongs to the Special Issue Advanced Materials Science and Technology in Drug Delivery)
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