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Advanced Biodegradable Polymer Scaffolds for Tissue Engineering, 3rd Edition

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (15 April 2026) | Viewed by 995

Special Issue Editor


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Guest Editor
Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania
Interests: nanomaterials; biomaterials for tissue regeneration; wound dressings; antimicrobial activity; biomimetic materials; biogenic calcium sources; composite scaffolds
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Special Issue Information

Dear Colleagues,

With its multidisciplinary approach, this Special Issue aims to gather the most recent and important knowledge in top-priority scientific fields such as health and emerging technologies. Tissue and organ regeneration are still a challenge in contemporary medical practices. There are currently numerous treatment options, which include the possibility of transplantation, mechanical devices, artificial prostheses, surgery, and drug therapy; however, when discussing significant levels of tissue damage, a major issue is represented by the development of biodegradable scaffolds, with proper mechanical and biological properties, to create a balance between tissue resorption and formation. Apart from the biocompatibility of the implanted materials, another limitation arises from the high risk of infection associated with surgical intervention. This Special Issue will focus on modern synthesis routes and characterization techniques to design tissue regeneration materials with enhanced properties in terms of antimicrobial effect and biocompatibility requirements (e.g., 3D porous composite scaffolds with the controlled release of bioactive compounds, scaffolds based on biotemplates, or naturally derived biomaterials, with the potential to mimic the native tissue).

Dr. Ionela Andreea Neacsu
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymers
  • scaffolds
  • composites
  • porous materials
  • wound dressings
  • 3D printing
  • biomedical applications
  • cell proliferation
  • biodegradability
  • tissue engineering

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Published Papers (1 paper)

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Review

53 pages, 2557 KB  
Review
Green and Scalable Manufacturing of Biodegradable Polymer Scaffolds: Solvent-Free Processing, Supercritical CO2 and Melt Electrowriting
by Kübra Arancı and Ahmet Akif Kızılkurtlu
Polymers 2026, 18(8), 974; https://doi.org/10.3390/polym18080974 - 16 Apr 2026
Viewed by 677
Abstract
Tissue scaffolds are one of the main components of the tissue engineering triad, playing a vital role in tissue engineering. However, their production procedures heavily rely on solvent-intensive and energy-demanding methods. This raises serious questions about industrial-scale manufacturability, residual solvent toxicity to living [...] Read more.
Tissue scaffolds are one of the main components of the tissue engineering triad, playing a vital role in tissue engineering. However, their production procedures heavily rely on solvent-intensive and energy-demanding methods. This raises serious questions about industrial-scale manufacturability, residual solvent toxicity to living health, and sustainability for nature and the environment. Therefore, the main aim of this study is to identify robust scaffolds that provide a suitable microenvironment for resident cells and promote tissue regeneration, while reducing waste through environmentally friendly production methods. In this context, the scalable and ecologically friendly production methods emerge as necessary alternatives as biodegradable polymer scaffolds are used in more therapeutic settings. Clinically applicable and green synthesis-based supercritical carbon dioxide (scCO2) technologies, melt electrowriting (MEW), and solvent-free processing techniques are the main topics of this study for a critical analysis of biodegradable polymer scaffold production techniques. Scaffold structure–property correlations, polymer selection and interactions, production procedures, the benefits and drawbacks of existing fabrication technologies, and sustainability issues are discussed in detail. It aims to contribute a novel perspective and approach to literature by presenting and comparing production-oriented approaches as sustainable and green methods. The challenges in the development of biodegradable tissue scaffolds, along with the significance of green manufacturing techniques, are also revealed. The approach is designed to connect processing factors to scaffold features in addition to evaluating current technologies. This review tries to offer a framework for producing biodegradable polymer scaffolds in a sustainable and clinically implementable context. Full article
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