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Volume 16
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10.3390/pharmaceutics16060769
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Review

The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment

by
Iria Seoane-Viaño
1,2,*,
Mariola Seoane-Gigirey
1,
Carlos Bendicho-Lavilla
1,2,
Luz M. Gigirey
3,
Francisco J. Otero-Espinar
1,2 and
Santiago Seoane-Trigo
4,*
1
Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, and Institute of Materials (iMATUS), University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain
2
Paraquasil Group (GI-2109), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain
3
Department of Applied Physics, Faculty of Optics and Optometry, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain
4
Ph. Dr. Adult Comprehensive Dentistry, University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2024, 16(6), 769; https://doi.org/10.3390/pharmaceutics16060769
Submission received: 7 April 2024 / Revised: 31 May 2024 / Accepted: 3 June 2024 / Published: 5 June 2024
(This article belongs to the Special Issue Advanced Materials Science and Technology in Drug Delivery)
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Abstract

Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on various factors, comorbidities, and poor oral health. Prophylaxis and different treatment methods have been widely discussed in recent decades, and surgical and non-surgical techniques present both advantages and disadvantages. In this work, a literature review of different studies on the application of adjuvant treatments, such as local and systemic antibiotics and antiseptic treatments, was conducted. Positive outcomes have been found in the short (up to one year after treatment) and long term (up to ten years after treatment) with combined therapies. However, there is still a need to explore new therapies based on the use of advanced drug delivery systems for the effective treatment of peri-implantitis in the long term and without relapses. Hence, micro- and nanoparticles, implants, and injectable hydrogels, among others, should be considered in future peri-implantitis treatment with the aim of enhancing overall therapy outcomes.
Keywords: peri-implantitis; dental implant surface and periodontal pocket; adjuvant therapies; bleeding on probing; implants and injectable hydrogels; nanoparticles and microparticles peri-implantitis; dental implant surface and periodontal pocket; adjuvant therapies; bleeding on probing; implants and injectable hydrogels; nanoparticles and microparticles

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MDPI and ACS Style

Seoane-Viaño, I.; Seoane-Gigirey, M.; Bendicho-Lavilla, C.; Gigirey, L.M.; Otero-Espinar, F.J.; Seoane-Trigo, S. The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment. Pharmaceutics 2024, 16, 769. https://doi.org/10.3390/pharmaceutics16060769

AMA Style

Seoane-Viaño I, Seoane-Gigirey M, Bendicho-Lavilla C, Gigirey LM, Otero-Espinar FJ, Seoane-Trigo S. The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment. Pharmaceutics. 2024; 16(6):769. https://doi.org/10.3390/pharmaceutics16060769

Chicago/Turabian Style

Seoane-Viaño, Iria, Mariola Seoane-Gigirey, Carlos Bendicho-Lavilla, Luz M. Gigirey, Francisco J. Otero-Espinar, and Santiago Seoane-Trigo. 2024. "The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment" Pharmaceutics 16, no. 6: 769. https://doi.org/10.3390/pharmaceutics16060769

APA Style

Seoane-Viaño, I., Seoane-Gigirey, M., Bendicho-Lavilla, C., Gigirey, L. M., Otero-Espinar, F. J., & Seoane-Trigo, S. (2024). The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment. Pharmaceutics, 16(6), 769. https://doi.org/10.3390/pharmaceutics16060769

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