Special Issue "Glycosaminoglycans and Proteoglycans"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (30 April 2017) | Viewed by 52896
A printed edition of this Special Issue is available here.
Interests: complex glycans; sulphated polysaccharides; glycosaminoglycans; structural biology; NMR spectroscopy; molecular modelling
Proteoglycans (PGs) are glycoconjugates in which a protein or peptide core is substituted with polysaccharide chains known as glycosaminoglycans (GAGs). The GAG sidechains carry a significant proportion of the functionality of PGs, interacting with many proteins to form structural units in the extracellular matrix and to modulate the transport and signalling of small proteins acting as morphogens, growth factors and cytokines. Purified GAGs such as heparin and hyaluronan are in common use as therapeutic agents, with many more PG-based natural products, synthetic and semi-synthetic mimetics on the way; in addition, potential therapeutic strategies involving PG/GAG biosynthesis and degradation as targets are currently in development.
Potential contributors are invited to submit papers concerning PGs, GAGs or their mimetics in any pharmaceutical or related context. Particularly welcome will be studies involving whole PGs, the chondroitin sulfates, dermatan sulfate and keratan sulfate, though the mainstream areas of heparin and other sulfated polysaccharides in anticoagulation will also be represented.
I look forward to reading your submission.
Prof. Dr. Barbara Mulloy
Manuscript Submission Information
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