Next Article in Journal
Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression
Next Article in Special Issue
CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells
Previous Article in Journal
Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging
Previous Article in Special Issue
Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors
Open AccessReview

The Multi-Functional Calcium/Calmodulin Stimulated Protein Kinase (CaMK) Family: Emerging Targets for Anti-Cancer Therapeutic Intervention

Priority Research Centre for Cancer Research, Innovation and Translation, School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute (HMRI) and University of Newcastle, Callaghan, NSW 2308, Australia
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2019, 12(1), 8; https://doi.org/10.3390/ph12010008
Received: 10 December 2018 / Revised: 2 January 2019 / Accepted: 4 January 2019 / Published: 7 January 2019
(This article belongs to the Special Issue Protein Kinases and Cancer)
The importance of Ca2+ signalling in key events of cancer cell function and tumour progression, such as proliferation, migration, invasion and survival, has recently begun to be appreciated. Many cellular Ca2+-stimulated signalling cascades utilise the intermediate, calmodulin (CaM). The Ca2+/CaM complex binds and activates a variety of enzymes, including members of the multifunctional Ca2+/calmodulin-stimulated protein kinase (CaMK) family. These enzymes control a broad range of cancer-related functions in a multitude of tumour types. Herein, we explore the cancer-related functions of these kinases and discuss their potential as targets for therapeutic intervention. View Full-Text
Keywords: CaMKK; CaMKI; CaMKII; CaMKIV; anti-cancer drugs CaMKK; CaMKI; CaMKII; CaMKIV; anti-cancer drugs
Show Figures

Figure 1

MDPI and ACS Style

Brzozowski, J.S.; Skelding, K.A. The Multi-Functional Calcium/Calmodulin Stimulated Protein Kinase (CaMK) Family: Emerging Targets for Anti-Cancer Therapeutic Intervention. Pharmaceuticals 2019, 12, 8.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop