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Open AccessArticle

Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response

by George S. Scaria 1,†, Betsy T. Kren 1,† and Mark A. Klein 1,2,3,*
1
Research Service, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA
2
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
3
Hematology/Oncology Section, Primary Care Service Line, Minneapolis VA Health Care System, Minneapolis, MN 55417, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
Pharmaceuticals 2020, 13(2), 26; https://doi.org/10.3390/ph13020026
Received: 1 January 2020 / Revised: 26 January 2020 / Accepted: 30 January 2020 / Published: 5 February 2020
(This article belongs to the Collection Protein Kinases and Cancer)
Pancreatic cancer, hepatocellular carcinoma (HCC), and mesothelioma are treatment-refractory cancers, and patients afflicted with these cancers generally have a very poor prognosis. The genomics of these tumors were analyzed as part of The Cancer Genome Atlas (TCGA) project. However, these analyses are an overview and may miss pathway interactions that could be exploited for therapeutic targeting. In this study, the TCGA Pan-Cancer datasets were queried via cBioPortal for correlations among mRNA expression of key genes in the cell cycle and mitochondrial (mt) antioxidant defense pathways. Here we describe these correlations. The results support further evaluation to develop combination treatment strategies that target these two critical pathways in pancreatic cancer, hepatocellular carcinoma, and mesothelioma.
Keywords: hepatocellular carcinoma; pancreatic neoplasms; mesothelioma; genome; cell cycle; reactive oxygen species; mitochondria hepatocellular carcinoma; pancreatic neoplasms; mesothelioma; genome; cell cycle; reactive oxygen species; mitochondria
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Scaria, G.S.; Kren, B.T.; Klein, M.A. Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response. Pharmaceuticals 2020, 13, 26.

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