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Pharmaceuticals 2019, 12(1), 4; https://doi.org/10.3390/ph12010004

Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors

Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
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Received: 15 November 2018 / Revised: 17 December 2018 / Accepted: 17 December 2018 / Published: 1 January 2019
(This article belongs to the Special Issue Protein Kinases and Cancer)
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Abstract

The need for new drugs is compelling, irrespective of the disease. Focusing on medical problems in the Western countries, heart disease and cancer are at the moment predominant illnesses. Owing to the fact that ~90% of all 21,000 cellular proteins in humans are regulated by phosphorylation/dephosphorylation it is not surprising that the enzymes catalysing these reactions (i.e., protein kinases and phosphatases, respectively) have attracted considerable attention in the recent past. Protein kinases are major team players in cell signalling. In tumours, these enzymes are found to be mutated disturbing the proper function of signalling pathways and leading to uncontrolled cellular growth and sustained malignant behaviour. Hence, the search for small-molecule inhibitors targeting the altered protein kinase molecules in tumour cells has become a major research focus in the academia and pharmaceutical companies. View Full-Text
Keywords: protein kinase; cancer; phosphorylation; natural compounds; flavonoids; kinase inhibition; cellular signalling protein kinase; cancer; phosphorylation; natural compounds; flavonoids; kinase inhibition; cellular signalling
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Guerra, B.; Issinger, O.-G. Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors. Pharmaceuticals 2019, 12, 4.

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