Dopamine and Serotonin Receptors: Selective or Multitarget Ligands for the Treatment of Central Nervous System Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 July 2024 | Viewed by 521
Special Issue Editors
Interests: receptor chemistry; drug discovery; biologically active ligands; structure-activity relationship studies
Special Issue Information
Dear Colleagues,
Dopamine and serotonin neurotransmitter pathways play important roles in regulating several physiological functions in the central nervous system and are altered in numerous complex diseases, including psychiatric and neurodegenerative disorders. An efficacious strategy in the treatment of such pathologies involves the discovery and development of ligands selectively targeting dopamine or serotonin receptor subtypes, with limited side effects (“magic bullets”).
However, the multitarget or “magic shotgun” approach, combining dopamine and serotonin receptor systems, might produce improved results in the treatment of polyfactorial pathologies. Indeed, with respect to combined therapies, multitarget drugs may offer clear advantages, including reduced risk of drug interactions, more predictive pharmacokinetics, and better patient compliance.
In this Special Issue, authors are invited to submit original articles dealing with the discovery and/or development of subtype selective or multitarget ligands targeting dopamine and/or serotonin receptors potentially useful for the treatment of central nervous system diseases. Review articles focused on the recent findings concerning this area of investigation will also be welcome.
Dr. Fabio Del Bello
Dr. Wilma Quaglia
Guest Editors
Manuscript Submission Information
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Keywords
- dopamine and serotonin neurotransmission
- selective dopamine receptor ligands
- selective serotonin receptor ligands
- multitarget agents
- central nervous system pathologies
- psychiatric disorders
- neurodegenerative diseases
