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Materials for Bone and Dental Hard Tissue Substitutes—2nd Edition

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 584

Special Issue Editor


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Guest Editor
Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
Interests: nanomaterials; titanium alloys; composites; nanohydroxyapatite applications; scaffolds; dental CAD/CAM materials; bone regeneration; dental bioengineering; biomaterial’s surface modification; lasers in medicine; environmental dentistry
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Special Issue Information

Dear Colleagues,

Bone and dental hard tissue defects still remain a challenge in regenerative medicine. Moreover, modern materials used in endodontics and endoprosthodontics allow for the regeneration of dental tissues, which prolongs a tooth’s usefulness. The technological progress of materials influences the efficacy of implantology by supressing the resorption of alveolar bone. Modern technologies in materials are also successfully used in the case of mandible or maxilla reconstruction. 

The aim of this Special Issue should be discussed in articles on the possible use of mineralized tissue substitutes in biomedicine. The successful use of bone substitute material allows for the natural duplication of the bone cellular system. Better understanding of bony nanostructure contributes to the more efficient use of synthetic biomaterials as bone substitutes. Special attention will be paid to new methods of nanomaterials use in bone substitution, as well as their effectiveness in clinical procedures.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Characterization of bone substitute materials;
  • Application of bone substitute materials;
  • Biocompatibility assessment of bone substitute materials;
  • Physicochemical properties of bone substitute materials;
  • Nanoscale modifications of bone substitute materials;
  • Three-dimensional printing in bone regeneration;
  • Modern titanium alloys in maxilla or mandible reconstructions;
  • Materials in endodontic surgery;
  • Mechanical and biocompatible properties of CAD/CAM restorative materials;
  • Materials in osteosynthesis and implantology.

Dr. Maciej Dobrzyński
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydroxiapatite
  • alloplastic materials
  • xenografts
  • nanomaterials-based bone regeneration
  • 3D-printed scaffolds
  • dental implants
  • titanium alloys
  • endodontic materials
  • dental CAD/CAM materials

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Published Papers (1 paper)

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Research

18 pages, 14164 KiB  
Article
Assessment of the Physico-Chemical, Microbial, and Cytotoxic Characteristics of Zirconia Crowns Utilized in Pediatric Dentistry
by Klaudia Sztyler, Magdalena Pajączkowska, Joanna Nowicka, Agnieszka Rusak, Grzegorz Chodaczek, Łukasz Dubniański, Anna Nikodem, Rafal J. Wiglusz, Adam Watras and Maciej Dobrzyński
Appl. Sci. 2025, 15(10), 5444; https://doi.org/10.3390/app15105444 - 13 May 2025
Viewed by 158
Abstract
Zirconia crowns are employed in pediatric dentistry for the complete restoration of anterior and posterior deciduous teeth. They are considered the best option due to their esthetic appeal, high strength, biocompatibility, and resistance to wear and corrosion. This study aims to evaluate the [...] Read more.
Zirconia crowns are employed in pediatric dentistry for the complete restoration of anterior and posterior deciduous teeth. They are considered the best option due to their esthetic appeal, high strength, biocompatibility, and resistance to wear and corrosion. This study aims to evaluate the physico-chemical, cytological, and microbial properties of zirconia crowns to determine their biocompatibility, safety for surrounding tissues, and effectiveness in preventing microbial influence on tooth tissue based on their biofilm deposition potential. XRD measurements were conducted to confirm the crown composition. For the microbiological examination, a quantitative assessment of the adhesion capacity of the analyzed strains and the formation of a mixed biofilm was performed using a Zeiss Cell Observer SD confocal microscope. This study used a mixed biofilm containing Streptococcus mutans (ATCC 25175), Lactobacillus rhamnosus (ATCC 9595), Candida albicans (ATCC 90028), and Candida albicans (ATCC 10231) to simulate the oral environment and the possible dynamics created between different types of microorganisms. A direct contact method was used to assess cytotoxic properties. The zirconia crown biomaterial shows a low ability to adhere to specific microorganisms, with L. rhamnosus predominating, indicating low clinical potential for causing inflammation of the tissues surrounding the crown. The cytotoxic properties of the biomaterial were found to be at level 2, indicating moderate cytotoxicity. Their biggest flaws are price and the need for passive fitting, which involves aggressive grinding; this is a potential limitation when it occurs in children, as their cooperation with the treatment can be difficult to guarantee. Full article
(This article belongs to the Special Issue Materials for Bone and Dental Hard Tissue Substitutes—2nd Edition)
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