Special Issue "Virus-Host Interactions and Pathogenesis of Arbovirus"
Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 6172
Interests: arbovirus; viral tropical diseases; virus-host interactions and pathogenesis; One Health
Interests: arbovirus; viral hemorrhagic fevers; immune responses to viruses; virus-host interactions; pathogenesis of arbovirus
Emerging and re-emerging infectious diseases are a major concern in human and animal health. Among them, viruses transmitted by hematophagous arthropods, known as arthropod-borne viruses (arboviruses), represent a significant source of zoonotic diseases and a serious threat to public and animal health worldwide. Global changes, due to an increase in human activities that impact wildlife habitats, are promoting pathogen spillover from wildlife, the risk of the emergence of viruses, and their global dissemination. For instance, dengue virus incidence remains very high throughout tropical and subtropical areas and it is still spreading to new areas, while other viruses, such as yellow fever, West Nile, Usutu, Japanese encephalitis, and bluetongue, cause morbidity and mortality in humans, domestic animals, and wildlife worldwide.
However, the global spread of arboviruses is also due to their intrinsic characteristics that allow for the transmission, infection, and replication of these viruses in vertebrate hosts prior to the subsequent rounds of transmission and replication cycles. Changes in virus-derived non-structural protein-1 have been shown to enhance viral replication in mosquito vectors and facilitate transmission to mammalian hosts. Several viral proteins have been shown to interact with the host’s innate immune system to evade the detection of the virus and enhance viral replication. Further mutation in viral genomes has been linked to the emergence of novel clinical manifestations, such as the effects of intrauterine infection with Zika virus. A better understanding of virus–host interactions and molecular mechanisms remains crucial to elucidating the global pathogenesis of arboviruses, preventing their emergence, and addressing their impacts on human and animal health.
In this Special Issue, we aim to publish studies on virus–host and virus–vector interactions and the pathogenesis of arboviruses in humans and animals, including newly emerging arboviruses. Original research papers, review articles, and short communications are welcome.
Dr. Rodolphe Hamel
Dr. Anon Srikiatkhachorn
Manuscript Submission Information
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- virus-host interactions and viral replication
- host immunity
- host factors