Special Issue "Candida Albicans Infections"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 June 2015).
Interests: mechanisms of IL-17 receptor signal transduction; role of IL-17 in immunity to oral Candida albicans infections
Immune responses to fungi remain poorly understood, and research in this field has lagged behind that of other microorganisms. To date, there are still no available vaccines or effective immunomodulatory strategies to prevent or treat fungal infections. The impact of fungal pathogens was highlighted in a 2012 outbreak of tainted epidural steroids, which affected almost 700 patients and caused 45 deaths (www.cdc.gov). Studies in the past few years have identified several common—but previously unappreciated—principles that appear to apply broadly to fungal immunity; in particular, the use of C-type lectin receptors (CLRs) as pattern recognition receptors (PRRs) and the importance of Th17-based responses to fungi. The most common fungal infections in humans are caused by Candida albicans, a commensal fungus that colonizes the mouth, skin and other mucosa of most healthy adults. The principles of immunity (CLRs, IL-17) defined for Candida have been found to apply to many other fungi as well, making studies of this organism an appealing model for understanding immunity to fungal pathogens more broadly. For this Special Issue of Pathogens, we invite you to submit a review article related to the microbial pathogenesis of Candida species, and we look forward to your contribution.
Prof. Dr. Sarah Gaffen
Manuscript Submission Information
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- Candida albicans
- fungal immunology
- T cells
- innate immunity
- animal models
- C-type lectin receptors