Advanced Research on Clostridium difficile
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 13310
Special Issue Editor
Special Issue Information
Dear Colleagues,
Clostridioides difficile infection (CDI) is the biggest clinical and therapeutic problem among hospitalized patients, especially the elderly population. Researchers have recently begun to pay attention to toxigenicity, sporulation, biofilm formation, and increasing antibiotic resistance of infective C. difficile strains. The next important issue is diagnostics as, regardless of known diagnostic algorithms, discordances may be observed between different tests. The epidemiological situation in Europe and around the world is changing, so different hyperepidemic ribotypes of C. difficile are circulated in different countries. These strains have an increased ability to sporulate, and C. difficile spores can remain in a hospital environment for months and years. The organization of significant disinfection procedures to eliminate spores is an additional problem. Treatment of CDI is not always simple, regardless of well-known active antibiotics and recently proposed new treatment schemes. Recurrences of CDI (rCDI) are common, and treatment is not easy. Fecal microbiota transplantation (FMT) is a very effective treatment used in different cases; however, some doubts are also noted. Another important problem is the fact that many domestic and wild animals serve as an additional source of C. difficile. This Special Issue of Pathogens will focus on the characteristics of this anaerobic bacterium, its toxins and other virulence factors, antibiotic resistance, diagnosis of CDI, treatment possibilities, and new options and the development of a vaccine.
Prof. Dr. Gayane Martirosian
Guest Editor
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Keywords
- Clostridioides difficile
- Clostridioides difficile infection (CDI)
- toxins
- virulence factors
- antibiotic resistance
- diagnosis
- treatment
- new options and development of a vaccine
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