Special Issue "Signaling Systems in Pseudomonas aeruginosa Biofilm"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 October 2017).
Interests: signaling systems; quorum sensing; biofilm; Pseudomonas aeruginosa; antimicrobial research; anti-virulence; quorum sensing inhibition
Interests: biofilm regulation; biofilm genetics; cell signaling reporter systems
Up until the 1970s, bacteria were understood to live as single organisms (planktonic mode of life), floating or actively swimming in their respective environments. This perception was challenged by the discovery that bacteria can live as organized aggregated communities, termed biofilms, and today the biofilm mode of growth is considered the favored life form of bacteria. Biofilm formation in the environment is believed to be an ancient strategy by which bacteria increase their survival potential in hostile environments. Extensive investigations support this to also be valid for biofilm related infections where the bacteria show highly elevated tolerance towards antibiotics and the immune system, compared with planktonic cells. Several signaling systems have been shown to be involved in different aspects of biofilm formation and maintenance, not least Quorum Sensing (QS) and cyclic-di-GMP. The importance of such signaling systems is supported by the growing identification of how factors regulated by these systems favor survival potentials of pathogens like Pseudomonas aeruginosa. Our knowledge of signaling systems is constantly evolving and new components taking part in the regulation are discovered.
Treatment of biofilm infections is significantly more difficult and complex compared to the relatively simple task of treating acute infections. Inhibition of signaling systems like QS and cyclic-di-GMP has gained considerable attention as potential approaches in the attempt to develop new strategies against biofilms. This Special Issue in Pathogens on “Signaling Systems in Pseudomonas aeruginosa Biofilm” centers on the newest studies and current knowledge about the influence of signaling systems on P. aeruginosa biofilm, both in vitro and in vivo, as well as on the potential of modulating these regulatory systems to lower biofilm survival. We invite you to submit a research or review manuscripts covering these important molecular aspects of P. aeruginosa biofilm and look forward to contributions that can increase our understanding and knowledge of this important scientific field.
Prof. Dr. Tim Holm Jakobsen
Prof. Jens Bo Andersen
Manuscript Submission Information
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- signaling systems
- quorum sensing
- Gac/rsm cascade
- Pseudomonas aeruginosa
- quorum sensing inhibitors
- cyclic-di-GMP inhibitors