Virus–Host Interactions: Antivirals and Diagnostics

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 269

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, College of Medicine, Chang Gung University, Tao Yuan 33302, Taiwan
Interests: molecular biology; antiviral drug development; molecular cell biology; cancer biology; microbiology; mitosis; yeast molecular genetics; protein biochemistry
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Special Issue Information

Dear Colleagues,

Viral infectious diseases are a major concern in human and animal health due to their wide distribution, ease of transmission, and difficult control strategies. Early diagnosis is the critical factor for efficient treatment of virus-related diseases. Developing new assays is particularly interesting; timely and accurate diagnosis is crucial for preventing unnecessary therapies. Accordingly, there is a growing need to update emerging diagnostics to help identify newer uncharacterized viruses. Developing novel antiviral strategies also poses an important challenge to the current healthcare system; understanding the mechanisms of virus–host interaction is essential to controlling viral infections and developing antivirals. 

We aim to publish virus–host interaction studies focusing on antivirals and diagnostics in this Special Issue. Both original research papers and review articles are welcome.

Dr. Robert Yung-Liang Wang
Guest Editor

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Keywords

  • viruse
  • virus–host interaction
  • antivirals
  • diagnostics
  • antiviral drug development

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Published Papers (1 paper)

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15 pages, 2010 KiB  
Systematic Review
Association Between IL-28B (rs8099917) and IL-28B (rs12979860) with Predisposition to Diseases Related to the HTLV-1: Systematic Review and Meta-Analysis
by Naomi Cuenca, Damarys Cordero and Brenda López-Ulloa
Pathogens 2025, 14(5), 470; https://doi.org/10.3390/pathogens14050470 - 13 May 2025
Abstract
This research addresses IL-28B gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1’s impact on immunity, this study seeks biomarkers for early [...] Read more.
This research addresses IL-28B gene polymorphisms (rs12979860 and rs8099917) to determine their association with HTLV-1-related diseases; it aims to compare genotypic frequencies to identify predisposition or protection, considering population, disease, and controls. Given HTLV-1’s impact on immunity, this study seeks biomarkers for early diagnosis and intervention. A systematic search met inclusion criteria, such as open access bibliographic and experimental studies published in English between 2010 and 2024, and genetic factors linked to susceptibility to pathologies. Regarding exclusion criteria, bibliographic or experimental studies in organisms other than humans, unofficial sources, non-indexed journals, and scientific articles in languages other than English were ruled out. Statistical data analyses were assessed using meta-analysis, including forest plot and Q test of heterogeneity based on the I2 statistics. The analyzed data indicate associations between genotypes, such as CT, GG, CC, and TT of the rs12979890 and rs8099917 polymorphisms and the predisposition to various diseases, such as HCV, arthropathy, HAM/TSP, cytomegalovirus and Crimean–Congo hemorrhagic fever associated with HTLV-1; however, the observed inconsistencies, such as high heterogeneity, and deficiency of related information limit the consolidation of the findings. Further research is needed to clarify IL-28B genotype interactions and disease susceptibility in HTLV-1 infections. Full article
(This article belongs to the Special Issue Virus–Host Interactions: Antivirals and Diagnostics)
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