Special Issue "Pathogenesis and Virulence of Candida albicans and Candida glabrata"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 April 2018).
Interests: Non-Candida albicans Candida species; virulence factors; biofilms; antifungal resistance; natural antimicrobial agents; host interaction; biomaterials
Special Issues and Collections in MDPI journals
Candida species form part of the normal microbiota of an individual’s oral cavity, gastrointestinal, urinary and vaginal tracts. While normally harmless, conditions may arise that facilitate Candida infection (candidosis), which may manifest superficially at mucosal surfaces, or systemically. The incidence of human candidosis has increased in recent decades and whilst superficial infections are more prevalent, systemic infections have a much morbidity and mortality. Important risk factors for development of systemic infection include the more widespread use of invasive medical devices, an increase use of parenteral nutrition, higher occurrence of immunosuppression diseases, and greater use of chemo- and radiotherapies. To cause infection, Candida possess several virulence factors, and these include filamentous or hyphal growth, secretion of hydrolases, and an ability to adhere and produce biofilm on host surfaces.
In clinical infection, Candida albicans is the most commonly encountered species of Candida, with an incidence of approximately 47% in all candidoses. However, in recent decades, the number of infections caused by non-Candida albicans Candida species has increased significantly, and in this regard Candida glabrata has been prominent. Although C. glabrata lacks some of the virulence factors associated with C. albicans pathogenicity, such as hyphal growth and secreted hydrolases, it can be extremely resistant to antifungals. Moreover, C. glabrata has often found to be co-isolated with C. albicans where increased pathogenicity has been noted. Due to the high significance of Candida infections, especially those caused by C. albicans and C. glabrata, we would like to receive your contributions on this field, to promote increased understanding and awareness within this extremely important subject.
Prof. Dr. Mariana Henriques
Prof. Dr. David Williams
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Candida albicans
- Candida glabrata
- Candida infection
- virulence factors