From Gastroenteritis to Emerging Threats: One Health Surveillance of Viral Infections

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1941

Special Issue Editors


E-Mail Website
Guest Editor
Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, São Paulo 01246-902, Brazil
Interests: viral fecal-borne disease; one health surveillance; interspecies transmission; enteric diseases; gastroenteritis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Instituto Adolfo Lutz, Centro de Patologia, São Paulo, Brazil
Interests: infectious diseases; yellow fever; zoonosis; new world primates; pathology; immunohistochemistry; diagnosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Viral gastroenteritis and other fecal-borne diseases represent a critical challenge at the nexus of human, animal, and environmental health. These diseases, caused by a diverse range of viruses, are characterized by symptoms such as diarrhea, stomach cramps, nausea, vomiting, and fever, and they impact both humans and a wide variety of animal species. Beyond gastroenteritis-causing agents such as rotavirus, norovirus, adenovirus, and astrovirus, other fecal-borne viruses, including hepatitis A and E, as well as SARS-CoV-2, have been documented to spread via fecal matter, adding layers of complexity to transmission dynamics and public health responses.

Transmission occurs predominantly through the fecal–oral route, either directly or indirectly, via contaminated water, food, or surfaces. Recent findings have highlighted the increasing frequency of interspecies transmission, where viruses cross species barriers, moving from animals to humans, among animal species, or even from humans to animals. These events underscore the urgent need for a One Health approach to understand and mitigate risks, addressing the interconnectedness of human, animal, and environmental health.

This Special Issue on "From Gastroenteritis to Emerging Threats: One Health Surveillance of Viral Infections" invites the submission of manuscripts focusing on various aspects of cross-species viral dynamics, including epidemiology, diagnosis, host–virus interactions, molecular epidemiology, pathogenesis, immunology, treatment, and prevention. Topics of interest include but are not limited to the following:

  • Interspecies transmission dynamics of enteric and fecal-borne viruses;
  • Surveillance and molecular epidemiology of viruses such as rotavirus, norovirus, hepatitis A and E, and SARS-CoV-2;
  • The role of potential animal reservoirs in viral dissemination;
  • Emergence and evolution of foodborne and waterborne viral pathogens;
  • The environmental impact of fecal-borne viruses on public health.;
  • Advances in prevention, treatment, and mitigation strategies;
  • Pathology and pathogenesis of viral gastroenteritis in humans and animals, both domestic and wildlife.

We strongly encourage submissions that embrace the One Health paradigm, fostering collaboration across the fields of human health, animal health, environmental science, and food safety.

Together, we can deepen our understanding of viral fecal-borne diseases and advance global health and security through interdisciplinary research and innovation.

We look forward to receiving your contributions to this Special Issue.

Dr. Adriana Luchs
Dr. Natalia Coelho Couto de Azevedo Fernandes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral gastroenteritis
  • pathology of viral infections
  • fecal-borne diseases
  • one Health
  • interspecies transmission
  • molecular epidemiology
  • zoonotic viruses
  • environmental surveillance
  • foodborne and waterborne pathogen

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

10 pages, 832 KB  
Article
Distribution of Rotavirus alphagastroenteritidis Strains in Blantyre, Malawi, During and After the COVID-19 Pandemic
by End Chinyama, Chimwemwe Mhango, Rothwell Taia, Landilani Gauti, Jonathan Mandolo, Flywell Kawonga, Ernest Matambo, Prisca Matambo, Innocent Chibwe, Richard Wachepa, Nigel A. Cunliffe, Chisomo L. Msefula and Khuzwayo C. Jere
Pathogens 2025, 14(11), 1169; https://doi.org/10.3390/pathogens14111169 - 16 Nov 2025
Viewed by 759
Abstract
Rotavirus alphagastroenteritidis remains the leading cause of severe gastroenteritis in children under five years, despite widespread vaccine use. The COVID-19 pandemic disrupted healthcare and vaccination delivery, while non-pharmacological interventions may have influenced R. alphagastroenteritidis transmission. We conducted hospital-based surveillance of R. alphagastroenteritidis gastroenteritis [...] Read more.
Rotavirus alphagastroenteritidis remains the leading cause of severe gastroenteritis in children under five years, despite widespread vaccine use. The COVID-19 pandemic disrupted healthcare and vaccination delivery, while non-pharmacological interventions may have influenced R. alphagastroenteritidis transmission. We conducted hospital-based surveillance of R. alphagastroenteritidis gastroenteritis at Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi, from October 2019 to October 2024. Children under five presenting with acute gastroenteritis were enrolled; 99.1% of vaccine-eligible participants had received at least one R. alphagastroenteritidis vaccine dose. Stool samples were tested for R. alphagastroenteritidis by enzyme immunoassay (EIA) and genotyped using RT-PCR. Among 1135 enrolled children, 29.1% (330/1135) were R. alphagastroenteritidis-positive. Cases occurred year-round except for December 2020–January 2021, when no R. alphagastroenteritidis infections were detected, and February–March 2023, when no samples were collected. The prevalence varied significantly by age group between children greater than 23 months of age to the rest of the age groups (<6 months, 6–11 months, and 12–22 months) (p = 0.0046). The most common R. alphagastroenteritidis G-genotypes were G3 (38.7%), G2 (25.4%), and G12 (17.2%), with G2 emerging as the predominant strain from June 2023. G3P[8] was the most frequent G–P combination (25%). Its overall prevalence did not change during the pandemic; however, genotype distribution shifted compared to pre-COVID-19 patterns. Sustained surveillance and genomic analyses are essential to monitor evolving strain dynamics and inform vaccine policy. Full article
Show Figures

Figure 1

27 pages, 3600 KB  
Article
TREM-1 Interacts with Rotavirus Proteins and Drives Inflammatory Responses: A Combined Experimental and Computational Approach
by Amanda de Oliveira Matos, José Rodrigues do Carmo Neto, Fernanda Craveiro Franco, Jefferson do Carmo Dietz, Pedro Henrique dos Santos Dantas, Andrei Giacchetto Felice, Adriana Luchs, Milton Adriano Pelli de Oliveira, Artur Christian Garcia da Silva, Siomar de Castro Soares, Simone Gonçalves da Fonseca, Fátima Ribeiro-Dias, Bruno Junior Neves, Carolina Horta Andrade, Marcelle Silva-Sales and Helioswilton Sales-Campos
Pathogens 2025, 14(10), 1029; https://doi.org/10.3390/pathogens14101029 - 10 Oct 2025
Viewed by 825
Abstract
Rotavirus (RV) is one of the main etiologic agents associated with diarrheal diseases (DDs), being responsible for approximately 200 thousand deaths annually. Currently, there are still many aspects regarding the virus biology, cell cycle, and pathophysiology of RV that need further elucidation. Therefore, [...] Read more.
Rotavirus (RV) is one of the main etiologic agents associated with diarrheal diseases (DDs), being responsible for approximately 200 thousand deaths annually. Currently, there are still many aspects regarding the virus biology, cell cycle, and pathophysiology of RV that need further elucidation. Therefore, the present work aimed to investigate whether the triggering receptor expressed on myeloid cells 1 (TREM-1) might be associated with RV infection. This immune receptor has been observed as an amplifier of inflammatory responses in different infectious and non-infectious diseases, including inflammatory bowel disease and celiac disease. Initially, we searched for public transcriptomic data regarding RV infection and the expression of TREM-1 and its associated genes, which were significantly upregulated in infected mice and children. Then, we infected monocytes with the virus, with or without a TREM-1 inhibitor. The inhibition of the receptor’s activity resulted in a significant decrease in IL-1β production. We also observed a reduction in cytopathic effects when MA104 cells were treated with TREM-1 inhibitors and then infected with simian RV. To further elucidate the interactions between the virus and TREM-1, in silico tools were used to simulate interactions between the receptor and RV proteins. These simulations suggested the occurrence of interactions between TREM-1 and VP5*, a protein involved in viral attachment to target cells, and also between the receptor and NSP4, a viral enterotoxin with immunostimulant properties. Hence, our results indicate that TREM-1 is involved in RV infection, both as a mediator of inflammatory responses and as a player in the host–virus relationship. Full article
Show Figures

Figure 1

Back to TopTop