Acanthamoeba Infections

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 989

Special Issue Editors


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Guest Editor
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Francisco Sánchez s/n, Campus de Anchieta, 38203 La Laguna Tenerife, Canary Islands, Spain
Interests: free-living amoebae; chemotherapy; programmed cell death; infectious diseases; Acanthamoeba

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Guest Editor
Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Francisco Sánchez s/n, Campus de Anchieta, 38203 La Laguna Tenerife, Canary Islands, Spain
Interests: free-living amoebae; chemotherapy, natural origin products; kinetoplastids
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Special Issue Information

Dear Colleagues,

Nowadays, Acanthamoeba infections pose significant challenges due to their resistance to conventional therapies and the severe pathologies that they cause. These free-living protozoans can lead to conditions such as Acanthamoeba keratitis, a severe infection of the corneal epithelium often associated with contact lens wearers, and granulomatous amoebic encephalitis, a rare but fatal brain infection. Current therapies against infections caused by this protozoan are often ineffective due to its high resistance to drugs and environmental conditions, the long periods needed to treat infections, and the side effects developed in patients.

Given these challenges, advancing our understanding of Acanthamoeba biology, pathogenic mechanisms, and treatment options is crucial. Researchers are invited to submit their findings to the journal Pathogens for inclusion in a Special Issue dedicated to Acanthamoeba infections. This Special Issue will compile cutting-edge research on diagnostic techniques, novel therapeutic strategies, and insights into the molecular and cellular interactions of Acanthamoeba with host tissues. By sharing these discoveries, we hope to foster collaboration and innovation, ultimately improving the management and outcomes of Acanthamoeba infections.

Dr. Rubén L. Rodríguez-Expósito
Dr. Ines Sifaoui
Guest Editors

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Keywords

  • Acanthamoeba 
  • mechanism of action
  • programmed cell death
  • in vivo research on Acanthamoeba infections
  • chemotherapy advances

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Published Papers (1 paper)

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Review

13 pages, 6620 KiB  
Review
Encystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement
by Mathew Choaji, Ascel Samba-Louaka, Zineb Fechtali-Moute, Willy Aucher and Sébastien Pomel
Pathogens 2025, 14(3), 268; https://doi.org/10.3390/pathogens14030268 - 10 Mar 2025
Viewed by 681
Abstract
The free-living amoeba Acanthamoeba castellanii is a unicellular eukaryote distributed in a wide range of soil or aquatic environments, either natural or human-made, such as rivers, lakes, drinking water, or swimming pools. Besides its capacity to transport potential pathogens, such as bacteria or [...] Read more.
The free-living amoeba Acanthamoeba castellanii is a unicellular eukaryote distributed in a wide range of soil or aquatic environments, either natural or human-made, such as rivers, lakes, drinking water, or swimming pools. Besides its capacity to transport potential pathogens, such as bacteria or viruses, Acanthamoeba spp. can have intrinsic pathogenic properties by causing severe infections at the ocular and cerebral level, named granulomatous amoebic encephalitis and amoebic keratitis, respectively. During its life cycle, A. castellanii alternates between a vegetative and mobile form, named the trophozoite, and a resistant, latent, and non-mobile form, named the cyst. The cyst wall of Acanthamoeba is double-layered, with an inner endocyst and an outer ectocyst, and is mainly composed of cellulose and proteins. The resistance of cysts to many environmental stresses and disinfection treatments has been assigned to the presence of cellulose. The current review aims to present the importance of this glycopolymer in Acanthamoeba cysts and to further report the pathways involved in encystment and excystment. Full article
(This article belongs to the Special Issue Acanthamoeba Infections)
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