Bacterial Pathogenesis and Antibiotic Resistance

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 863

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Guest Editor
Área de Microbiología, Departamento de Farmacia, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera—CEU, CEU Universities, Alfara del Patriarca, 46115 Valencia, Spain
Interests: antibiotic resistance; multidrug-resistant bacteria; clinical microbiology; clinical virology
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Special Issue Information

Dear Colleagues,

Bacterial pathogenesis and antibiotic resistance are critical topics in current biomedical research. In the context of growing concern about the efficacy of treatments, this Special Issue will address the molecular and cellular mechanisms underlying the ability of bacteria to cause disease, as well as the factors that facilitate the development and spread of antimicrobial resistance. Aspects such as the evolution of resistance, horizontal gene transfer, and innovative strategies to combat resistant infections through the development of alternative therapies or the design of next-generation antibiotics will be explored, with an emphasis on those that act on unconventional targets or through therapeutic synergies. In addition, the clinical implications and public health policies needed to address this growing threat will be discussed. This Special Issue invites researchers to present their original studies, reviews, and case analyses that provide a comprehensive and up-to-date view of these challenges and their possible solutions. 

Prof. Dr. María-Teresa Pérez-Gracia
Guest Editor

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Keywords

  • bacterial pathogenesis
  • antibiotic resistance
  • molecular mechanisms
  • therapeutic strategies
  • multidrug-resistant bacteria

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Published Papers (2 papers)

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Research

8 pages, 4134 KiB  
Communication
Genomic and Virulence Characteristics of Brucella intermedia Isolated from Hospital Wastewater in Ghana
by Runa Furuya, Satomi Takei, Yoko Tabe, Anthony Ablordey and Ryoichi Saito
Pathogens 2025, 14(6), 522; https://doi.org/10.3390/pathogens14060522 - 23 May 2025
Abstract
Brucella intermedia, a gram-negative, non-lactose-fermenting, aerobic, rod-shaped bacterium, is found in environmental sources (e.g., soil and water). In 2020, Ochrobactrum was reclassified as Brucella. We conducted a genomic analysis of B. intermedia from hospital wastewater samples in western Ghana. A hybrid [...] Read more.
Brucella intermedia, a gram-negative, non-lactose-fermenting, aerobic, rod-shaped bacterium, is found in environmental sources (e.g., soil and water). In 2020, Ochrobactrum was reclassified as Brucella. We conducted a genomic analysis of B. intermedia from hospital wastewater samples in western Ghana. A hybrid genome assembly was constructed integrating short-read data from DNA Nanoball sequencing with long-read sequences generated by Oxford Nanopore MinION technology. Identification and antimicrobial susceptibility profiles were determined using MicroScan autoSCAN-4 based on Clinical and Laboratory Standard Institute documents. ResFinder and CARD Resistance Gene Identifier (RGI) were used to identify antimicrobial resistance (AMR) genes, and BLAST and VFDB datasets were used to identify virulence factor genes. The complete genome had two chromosomes, no plasmid, and a high average nucleotide identity value (98.05%) with B. intermedia. Resistance to trimethoprim-sulfamethoxazole was revealed, the first report in this species. CARD RGI revealed the presence of AMR genes, including ANT(9)-Ic and adeF. Local BLAST analysis revealed Cgs, a B. melitensis virulence factor. B. intermedia is an opportunistic human pathogen clinically isolated several times, suggesting the importance of accurately identifying multidrug resistance. B. intermedia may possess virulence factors similar to those of B. melitensis. Further study is needed to fully elucidate its pathogenesis. Full article
(This article belongs to the Special Issue Bacterial Pathogenesis and Antibiotic Resistance)
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11 pages, 545 KiB  
Article
Prevalence and Antimicrobial Susceptibility of Salmonella in Retail Meat Collected from Different Markets in Sichuan, China
by Hang Zeng, Donghai Yang, Nanxi Huang, Yonglin Li, Jiazhen Chen, Zhongjia Yu, Jie Tang and Zhenju Jiang
Pathogens 2025, 14(3), 222; https://doi.org/10.3390/pathogens14030222 - 25 Feb 2025
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Abstract
Salmonella is one of the most significant zoonotic and foodborne pathogens, and it is the leading cause of bacterial diarrhea. In this study, 156 retail meat samples were collected from three supermarkets and one local wet market in Sichuan, China, including 96 chicken [...] Read more.
Salmonella is one of the most significant zoonotic and foodborne pathogens, and it is the leading cause of bacterial diarrhea. In this study, 156 retail meat samples were collected from three supermarkets and one local wet market in Sichuan, China, including 96 chicken samples and 60 pork samples. The prevalence of Salmonella in these samples was analyzed, and 91 samples (58.33%) tested positive, with 60 (62.5%) positive chicken samples and 31 (51.67%) positive pork samples. From these positive samples, 190 Salmonella isolates were confirmed by double PCR. Subsequent serotyping identified nine serovars, with the predominant ones being S. London (58.94%), S. Typhimurium (12.58%), and S. Enteritidis (10.60%). Antibiotic susceptibility test revealed that 168 isolates (88.42%) were resistant to at least one antibiotic, and 150 isolates (78.95%) were resistant to three or more antibiotics. The highest resistance rates were observed for ampicillin (83.16%), followed by tetracycline (76.31%) and trimethoprim/sulfamethoxazole (67.37%). In the disinfectant susceptibility test, Salmonella isolates exhibited higher resistance rates to benzalkonium bromide (100%) and benzalkonium chloride (97.37%), while showing a lower resistance rate to potassium monopersulfate triple salt (33.6%). These findings highlight the high prevalence of Salmonella and its significant resistance to antibiotics and disinfectants, indicating that effective measures must be implemented to ensure the microbiological safety of retail meat. Full article
(This article belongs to the Special Issue Bacterial Pathogenesis and Antibiotic Resistance)
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