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Pathogens
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Advanced Research on the Streptococcus mutans
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Advanced Research on the Streptococcus mutans

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 3089

Special Issue Editor

Prof. Dr. Jing Zou

E-Mail Website
Guest Editor
State Key Laboratory of Oral Disease, Sichuan University, Chengdu, China
Interests: mcriobiota of early childhood caries

Special Issue Information

Dear Colleagues,

Streptococcus mutans is considered the principal etiologic agent of dental caries with important virulence factors, such as strong adhesion, intracellular and extracellular polysaccharides synthesis, biofilm formation, acidogenicity, and aciduricity. In addition, S. mutans resides in biofilms, which is a diverse, multi-species, and dynamic environment that is constantly exposed to severe limitations in nutrition, fluctuations in temperature and pH, and challenges in osmotic and oxidative tensions. Therefore, to survive adverse environmental conditions, bacteria evolve through a wide range of rapid and adaptive responses, including carbohydrate utilization, temperature, and oxidative adaptability, etc. In addition to the cariogenic functions, S. mutans can enter the bloodstream and cause systemic infections occasionally, such as infective endocarditis. With this special issue, we set out to offer a better understanding of S. mutans and its pathogenicity and adaptability, as well as the potential agents against it, and to showcase recent advances in these areas (including, but are not limited to).

Prof. Dr. Jing Zou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Streptococcus mutans
  • pathogenicity
  • adaptability
  • mechanism
  • antimicrobial agents

Published Papers (2 papers)

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13 pages, 3530 KiB  
Article
Assessment of Polydopamine to Reduce Streptococcus mutans Adhesion to a Dental Polymer
by Santiago Arango-Santander, Carlos Martinez, Claudia Bedoya-Correa, Juliana Sanchez-Garzon and John Franco
Pathogens 2023, 12(10), 1223; https://doi.org/10.3390/pathogens12101223 - 8 Oct 2023
Cited by 1 | Viewed by 1103
Abstract
Bacterial adhesion to the surface of materials is the first step in biofilm formation, which will lead to conditions that may compromise the health status of patients. Recently, polydopamine (PDA) has been proposed as an antibacterial material. Therefore, the objective of the current [...] Read more.
Bacterial adhesion to the surface of materials is the first step in biofilm formation, which will lead to conditions that may compromise the health status of patients. Recently, polydopamine (PDA) has been proposed as an antibacterial material. Therefore, the objective of the current work was to assess and compare the adhesion of Streptococcus mutans to the surface of poly(methyl methacrylate) (PMMA) discs that were modified using PDA following a biomimetic approach versus smooth PDA-coated PMMA surfaces. In addition, an assessment of the growth inhibition by PDA was performed. PMMA discs were manufactured and polished; soft lithography, using the topography from the Crocosmia aurea leaf, was used to modify their surface. PDA was used to smooth-coat PMMA discs by dip-coating. The growth inhibition was measured using an inhibition halo. The surfaces were characterized by means of atomic force microscopy (AFM), the contact angle (CA), and Fourier-transform infrared spectroscopy (FTIR). Polydopamine exhibited a significant antibacterial effect when used directly on the S. mutans planktonic cells, but such an effect was not as strong when modifying the PMMA surfaces. These results open the possibility of using polydopamine to reduce the adhesion and growth of S. mutans, which might have important consequences in the dental field. Full article
(This article belongs to the Special Issue Advanced Research on the Streptococcus mutans)
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12 pages, 4173 KiB  
Article
Dose-Dependent Inhibitory Effect of Probiotic Lactobacillus plantarum on Streptococcus mutans-Candida albicans Cross-Kingdom Microorganisms
by Jianhang Bao, Xinyan Huang, Yan Zeng, Tong Tong Wu, Xingyi Lu, Gina Meng, Yanfang Ren and Jin Xiao
Pathogens 2023, 12(6), 848; https://doi.org/10.3390/pathogens12060848 - 20 Jun 2023
Cited by 1 | Viewed by 1529
Abstract
Dental caries is one of the most common chronic diseases worldwide. Streptococcus mutans and Candida albicans are two major pathogens associated with dental caries. Several recent studies revealed that Lactobacillus plantarum inhibits S. mutans and C. albicans in biofilms and in a rodent [...] Read more.
Dental caries is one of the most common chronic diseases worldwide. Streptococcus mutans and Candida albicans are two major pathogens associated with dental caries. Several recent studies revealed that Lactobacillus plantarum inhibits S. mutans and C. albicans in biofilms and in a rodent model of dental caries. The aim of this study was to investigate the dose-dependent effect of L. plantarum against S. mutans and C. albicans in a planktonic model that simulated a high-caries-risk clinical condition. Mono-, dual-, and multi-species models were utilized, with five doses of L. plantarum (ranging from 1.0 × 104 to 1.0 × 108 CFU/mL). Real-time PCR was used to assess the expression of the virulence genes of C. albicans and S. mutans and the genes of L. plantarum. Student’s t-tests and one-way ANOVA, followed by post hoc tests, were employed to compare the cell viability and gene expression among groups. A dose-dependent inhibition on C. albicans and S. mutans was observed with increased dosages of L. plantarum. L. plantarum at 108 CFU/mL demonstrated the highest antibacterial and antifungal inhibitory effect in the dual- and multi-species models. Specifically, at 20 h, the growth of C. albicans and S. mutans was suppressed by 1.5 and 5 logs, respectively (p < 0.05). The antifungal and antibacterial effects were attenuated in lower doses of L. plantarum (104–107 CFU/mL). The expression of C. albicans HWP1 and ECE 1 genes and S. mutans lacC and lacG genes were significantly downregulated with an added 108 CFU/mL of L. plantarum (p < 0.05). The addition of 108 CFU/mL L. plantarum further inhibited the hyphae or pseudohyphae formation of C. albicans. In summary, L. plantarum demonstrated dose-dependent antifungal and antibacterial effects against C. albicans and S. mutans. L. plantarum emerged as a promising candidate for the creation of novel antimicrobial probiotic products targeting dental caries prevention. Further research is warranted to identify the functional metabolites produced by L. plantarum at different dosages when interacting with C. albicans and S. mutans. Full article
(This article belongs to the Special Issue Advanced Research on the Streptococcus mutans)
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