Flea-Borne Pathogens and Their Impact on Infectious Diseases

A Special Issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: closed (31 May 2026) | Viewed by 1068

Editor


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Guest Editor
Department of Animal Biology, Vegetal Biology and Ecology, Faculty of Experimental Sciences, Universidad de Jaén, 23071 Jaén, Spain
Interests: ticks; ixodidae; flea; siphonaptera; infectious diseases; rickettsia; Bartonella

Special Issue Information

Dear Colleagues,

A range of infectious diseases affect millions of people each year. These pathogens, including viruses, bacteria, and parasites, are transmitted to humans and animals through the bites of infected arthropods, such as mosquitoes, ticks, lice, and fleas. While many vector-borne diseases are well known, such as malaria, yellow fever, dengue fever, and Lyme disease, it is crucial to recognize the significant impact of diseases specifically transmitted by fleas.

Flea-borne diseases, including Bartonella infections, Rickettsial diseases, and plague, substantially contribute to the burden of vector-borne illnesses. These diseases can lead to debilitating conditions, disabilities, and even death. The impact of flea-transmitted pathogens is far-reaching, placing a heavy burden on healthcare systems and economies worldwide.

Climate change, urbanization, and globalization have exacerbated the spread and intensification of vector-borne diseases, including those spread by fleas. Rising temperatures and altered rainfall patterns have expanded the geographical range of vectors, while increased travel and trade have facilitated the introduction of new pathogens to previously unaffected regions, potentially including flea-borne pathogens.

Controlling vector-borne diseases, including those transmitted by fleas, requires a multifaceted approach. This includes vector control measures, such as insecticide spraying and habitat modification, specifically targeting flea populations and other vectors. Disease surveillance, early diagnosis, and effective treatment are also essential. Public health education and community engagement are crucial for preventing the spread of these diseases, emphasizing the importance of flea control and awareness.

In conclusion, flea-borne pathogens represent a significant challenge to global health security. Addressing this challenge requires a coordinated effort involving governments, international organizations, researchers, and communities to implement effective prevention and control strategies, with specific focus on flea-related illnesses.

Prof. Dr. Francisco José Márquez
Guest Editor

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Keywords

  • vector-borne pathogens
  • infectious diseases
  • public health
  • epidemiology
  • fleas

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Published Papers (1 paper)

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Research

19 pages, 798 KB  
Article
Autonomic Dysfunction in Patients with Bartonella henselae IgM Seroreactivity: A Cross-Sectional Study
by Branislav Milovanović, Nikola Marković, Elizabeta Ristanović, Nikoleta Đorđevski, Sonja Atanasievska Kujović, Sulin Bulatović, Vasko Žugić, Maša Petrović and Milovan Bojić
Pathogens 2026, 15(7), 762; https://doi.org/10.3390/pathogens15070762 - 20 Jul 2026
Viewed by 432
Abstract
BackgroundBartonella henselae infection has been associated with a broad spectrum of neurological and autonomic manifestations, although its impact on autonomic nervous system function remains insufficiently characterized, and the aim of this study was to evaluate autonomic function in patients with polymorphic [...] Read more.
BackgroundBartonella henselae infection has been associated with a broad spectrum of neurological and autonomic manifestations, although its impact on autonomic nervous system function remains insufficiently characterized, and the aim of this study was to evaluate autonomic function in patients with polymorphic symptoms and Bartonella henselae IgM seroreactivity. Methods: In this cross-sectional study, 75 patients were compared with 75 age- and sex-matched healthy controls, and all participants underwent cardiovascular autonomic reflex testing, short-term (5 min) and long-term (24 h) heart rate variability analysis, and 24 h ambulatory blood pressure monitoring, while head-up tilt testing was performed in the Bartonella group. Results: Abnormal autonomic reflex tests were significantly more frequent in the Bartonella IgM-seroreactive group, particularly those reflecting parasympathetic function, while heart rate variability analysis demonstrated reduced high-frequency components and lower long-term variability indices, and head-up tilt testing revealed heterogeneous hemodynamic responses including orthostatic hypotension and pronounced blood pressure variability, with ambulatory monitoring additionally showing higher nighttime blood pressure values and reduced nocturnal dipping. Conclusions: These findings indicate a consistent pattern of autonomic imbalance characterized predominantly by parasympathetic impairment and altered blood pressure regulation in patients with Bartonella henselae IgM seroreactivity, although further studies are required to clarify underlying mechanisms and clinical implications. Full article
(This article belongs to the Special Issue Flea-Borne Pathogens and Their Impact on Infectious Diseases)
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