Organoids and Cancer Models
A special issue of Organoids (ISSN 2674-1172).
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1787
Special Issue Editor
2. Departments of Pathology and Urology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Interests: cell reprogramming; telomerase and telomeres; patient-derived models; cell therapies; living biobanks; viruses; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Traditional cancer models, including cell lines and animal models, have been widely used but have seen limited applications in both basic and clinical cancer research. Patient-derived model systems are needed for modeling human diseases and precision medicine. Genomics-based precision oncology only helps 2–20% of patients with solid cancer, and as such, functional diagnostics and patient-derived models are needed for precision cancer biology. Induced pluripotent stem cells (iPS), organoids, and conditional reprogramming (CR) are currently used widely for patient-derived cell models for disease and precision medicine. Both organoids and CR technologies have been cited in two NCI programs, the PDMR (Patient-Derived Cancer Model Repository) and HCMI (Human Cancer Models Initiative), the latter of which will be distributed through the ATCC. These cells can be easily manipulated in vitro, and thus, these patient-derived cells could be used for next-generation disease models. In this Special Issue, we will focus on the applications of organoids and other reprogrammed cells in cancer modeling and drug discovery.
Prof. Dr. Xuefeng Liu
Guest Editor
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Keywords
- patient-derived cells
- organoids
- iPS (induced pluripotent stem cells)
- CRC (conditionally reprogrammed cells)
- air–liquid interface cultures
- circulating tumor cells
- cancer modeling
- drug discovery
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