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Organoids, Volume 4, Issue 3

September 2025 - 7 articles

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Articles (7)

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Article

1,426 Views

12 Pages

Air–Liquid-Interface-Differentiated Human Nose Epithelium: The Benchmark Culture Model for SARS-CoV-2 Infection

Sarah L. Harbach,
Bang M. Tran,
Abderrahman Hachani,
Samantha Leigh Grimley,
Damian F. J. Purcell,
Georgia Deliyannis,
Joseph Torresi,
Julie L. McAuley and
Elizabeth Vincan

Organoids2025, 4(3), 21;https://doi.org/10.3390/organoids4030021

18 September 2025

COVID-19 has triggered the rapid adoption of human organoid-based tissue culture models to overcome the limitations of the commonly used Vero cell line that did not fully recapitulate SARS-CoV-2 infection of human tissues. As the primary site of SARS...

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Review

2,356 Views

21 Pages

Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair

Nikki Liddelow,
Jie Yu Tan and
Dustin J. Flanagan

Organoids2025, 4(3), 20;https://doi.org/10.3390/organoids4030020

5 September 2025

The stomach epithelium is a highly dynamic tissue that undergoes continuous self-renewal and responds robustly to injury through tightly regulated repair processes. Organoids have emerged as powerful tools for modelling gastrointestinal biology. This...

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Article

1,037 Views

11 Pages

Paraffin Embedding and Histological Analyses of Sw71-Spheroids as Human Blastocyst-like Surrogates

Marina Alexandrova,
Mariela Ivanova,
Martina Metodieva,
Antonia Terzieva and
Tanya Dimova

Organoids2025, 4(3), 19;https://doi.org/10.3390/organoids4030019

11 August 2025

Implantation studies are extremely important to solve reproductive problems since about 60% of abortions occur around this period. The 3D in vitro models emerge as closest to the in vivo structures and processes. Here, we constructed trophoblast Sw71...

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Review

1,588 Views

22 Pages

Applications of Organoids and Spheroids in Anaplastic and Papillary Thyroid Cancer Research: A Comprehensive Review

Deepak Gulwani,
Neha Singh,
Manisha Gupta,
Ridhima Goel and
Thoudam Debraj Singh

Organoids2025, 4(3), 18;https://doi.org/10.3390/organoids4030018

1 August 2025

Organoid and spheroid technologies have rapidly become pivotal in thyroid cancer research, offering models that are more physiologically relevant than traditional two-dimensional culture. In the study of papillary and anaplastic thyroid carcinomas, t...

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Article

1,022 Views

22 Pages

Mimicking Senescence Factors to Characterize the Mechanisms Responsible for Hair Regression and Hair Loss: An In Vitro Study

Giacomo Masi,
Camilla Guiducci and
Francesca Rescigno

Organoids2025, 4(3), 17;https://doi.org/10.3390/organoids4030017

11 July 2025

Background/Objectives: VitroScreenORA® (by VitroScreen srl) Dermo Papilla spheroids, based on two micro-physiological systems (non-vascularized DP and vascularized VASC-DP), were used to study the molecular mechanisms behind hair cycle regression...

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Review

2 Citations

9,905 Views

29 Pages

A Concise Review of Organoid Tissue Engineering: Regenerative Applications and Precision Medicine

Karnika Yogeswari Makesh,
Abilash Navaneethan,
Mrithika Ajay,
Ganesh Munuswamy-Ramanujam,
Arulvasu Chinnasamy,
Dhanavathy Gnanasampanthapandian and
Kanagaraj Palaniyandi

Organoids2025, 4(3), 16;https://doi.org/10.3390/organoids4030016

4 July 2025

Organoids are three-dimensional tissue culture models derived from stem cells, and they have become one of the most valuable tools in biomedical research. These self-organizing miniature organs mimic the structure−function properties of their i...

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Article

1,143 Views

21 Pages

Pyrvinium Pamoate and BCL-XL Inhibitors Act Synergistically to Kill Patient-Derived Colorectal Adenoma Organoids

Maree C. Faux,
Chenkai Ma,
Serena R. Kane,
Andre Samson,
Yumiko Hirokawa,
Ilka Priebe,
Leah Cosgrove,
Rajvinder Singh,
Michael Christie and
Gregor Brown
+ 2 authors

Organoids2025, 4(3), 15;https://doi.org/10.3390/organoids4030015

2 July 2025

Current systemic therapies for advanced colorectal cancer (CRC) have limited efficacy, so more effective strategies for the treatment and prevention of CRC are needed. The majority of colorectal cancers are initiated by mutations in Wnt signalling pa...

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