Special Issue "Choline: An Essential Nutrient for Human Health"
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 36345
Interests: behavioral neuroscience; learning and memory; memory; choline
Choline is an essential nutrient classified within the vitamin B complex, which regulates several functions relevant for maintaining human health from early life to aging. Choline plays a critical role in the synthesis of the phospholipid membrane critical for cell functions, it is the major source of methyl-donors relevant for epigenetic modifications of the genome, and it is the precursor of acetylcholine, being a ubiquitous neurotransmitter involved in attention, learning, and memory, among other cognitive processes.
Dietary choline availability regulates choline levels, which are relevant for early brain development and brain plasticity throughout life. Thus, choline dysregulation has been associated with lower cognitive performance; neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases; mental disorders; and aging cognitive decline. Choline-related functions seem to be also dysregulated in other clinical conditions, such as cancer, obesity, and immune system and cardiovascular diseases. Therefore, nutritional intervention is emerging as a promising treatment, either by regulating choline levels through maternal and adult choline supplementation or by acting on the bacterial metabolism of dietary choline throughout gut microbiota modifications. Animal and human research has provided evidence supporting the neuroprotective and cognitive enhancing effects of choline dietary supplementation at different developmental stages. Being such a wide field, more research is required for understanding the role of choline in human health, action mechanisms, interactions with other micronutrients, and potential value for disease management.
The aim of this Special Issue is to update our knowledge in the field and provide new insights based on animal and human research. Hence, we invite you to submit research articles, reviews, communications, and concept papers focused on the effect of dysregulation and dietary choline availability on health and disease.
Prof. Milagros Gallo
Manuscript Submission Information
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