Special Issue "Choline: An Essential Nutrient for Human Health"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editor

Prof. Milagros Gallo
Guest Editor
Department Psychobiology, Institute of Neurosciences, University of Granada, Spain
Interests: behavioral neuroscience; learning and memory; memory; choline

Special Issue Information

Dear Colleagues,

Choline is an essential nutrient classified within the vitamin B complex, which regulates several functions relevant for maintaining human health from early life to aging. Choline plays a critical role in the synthesis of the phospholipid membrane critical for cell functions, it is the major source of methyl-donors relevant for epigenetic modifications of the genome, and it is the precursor of acetylcholine, being a ubiquitous neurotransmitter involved in attention, learning, and memory, among other cognitive processes.

Dietary choline availability regulates choline levels, which are relevant for early brain development and brain plasticity throughout life. Thus, choline dysregulation has been associated with lower cognitive performance; neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases; mental disorders; and aging cognitive decline. Choline-related functions seem to be also dysregulated in other clinical conditions, such as cancer, obesity, and immune system and cardiovascular diseases. Therefore, nutritional intervention is emerging as a promising treatment, either by regulating choline levels through maternal and adult choline supplementation or by acting on the bacterial metabolism of dietary choline throughout gut microbiota modifications. Animal and human research has provided evidence supporting the neuroprotective and cognitive enhancing effects of choline dietary supplementation at different developmental stages. Being such a wide field, more research is required for understanding the role of choline in human health, action mechanisms, interactions with other micronutrients, and potential value for disease management.

The aim of this Special Issue is to update our knowledge in the field and provide new insights based on animal and human research. Hence, we invite you to submit research articles, reviews, communications, and concept papers focused on the effect of dysregulation and dietary choline availability on health and disease.

Prof. Milagros Gallo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • choline
  • diet
  • epigenetic
  • acetylcholine
  • neurodegeneration
  • development
  • microbiota

Published Papers

This special issue is now open for submission.
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