Alterations in One-Carbon Metabolism in Celiac Disease
1
Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Málaga, 29011 Malaga, Spain
2
Department of Experimental Medicine, Lleida Biomedical Research Institute (IRBLleida), University of Lleida (UdL), 25198 Lleida, Spain
3
Department of Pediatrics, University of Granada, 18071 Granada, Spain
4
Pediatric Gastroenterology and Nutrition Unit, Hospital Universitario Virgen de las Nieves, 18071 Granada, Spain
5
Instituto de Investigación Biosanitaria (ibs), 18071 Granada, Spain
6
Maternal and Child Health Network, Carlos III Health Institute, 28029 Madrid, Spain
7
Biomedical Research Centre (CIBM), Department of Physiology and “José MataixVerdú” Institute of Nutrition and Food Technology (INYTA), University of Granada, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3723; https://doi.org/10.3390/nu12123723
Received: 5 November 2020
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Revised: 29 November 2020
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Accepted: 30 November 2020
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Published: 2 December 2020
(This article belongs to the Special Issue Choline: An Essential Nutrient for Human Health)
Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD.
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Keywords:
amino acids; choline; celiac disease; folate cycle; mass spectrometry; methionine cycle; methionine savage pathway; transsulfuration pathway
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MDPI and ACS Style
Martín-Masot, R.; Mota-Martorell, N.; Jové, M.; Maldonado, J.; Pamplona, R.; Nestares, T. Alterations in One-Carbon Metabolism in Celiac Disease. Nutrients 2020, 12, 3723. https://doi.org/10.3390/nu12123723
AMA Style
Martín-Masot R, Mota-Martorell N, Jové M, Maldonado J, Pamplona R, Nestares T. Alterations in One-Carbon Metabolism in Celiac Disease. Nutrients. 2020; 12(12):3723. https://doi.org/10.3390/nu12123723
Chicago/Turabian StyleMartín-Masot, Rafael, Natàlia Mota-Martorell, Mariona Jové, José Maldonado, Reinald Pamplona, and Teresa Nestares. 2020. "Alterations in One-Carbon Metabolism in Celiac Disease" Nutrients 12, no. 12: 3723. https://doi.org/10.3390/nu12123723
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